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Plant+Learning+Activities
Lieferant:
Sigma-Aldrich
Beschreibung:
Florisil® für die Chromatographie, Supelco®
Artikel-Nr:
(BOSSBS-4985R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A350
Lokale Artikelnummer::
BOSSBS-4985R-A350
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A647
Lokale Artikelnummer::
BOSSBS-4985R-A647
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A555
Lokale Artikelnummer::
BOSSBS-4985R-A555
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-14278R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-14278R-A680
Lokale Artikelnummer::
BOSSBS-14278R-A680
Beschreibung:
GTPase activator activity.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
A versatile photolabile bifunctional reagent for investigating the active sites of sulphydryl enzymes,particularly those which poses a reactive cysteine residue at the active site.
Artikel-Nr:
(USBIP4256-31K)
Lieferant:
US Biological
Hersteller-Artikelnummer::
P4256-31K
Lokale Artikelnummer::
USBIP4256-31K
Beschreibung:
Anti-Plasminogen Activator Inhibitor Type 1 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(USBIP4256-34W)
Lieferant:
US Biological
Hersteller-Artikelnummer::
P4256-34W
Lokale Artikelnummer::
USBIP4256-34W
Beschreibung:
Anti-Plasminogen Activator Inhibitor Type 1 Rabbit Polyclonal Antibody
VE:
1 * 1 mL
Artikel-Nr:
(USBIF4208-57A)
Lieferant:
US Biological
Hersteller-Artikelnummer::
F4208-57A
Lokale Artikelnummer::
USBIF4208-57A
Beschreibung:
Anti-Fibroblast Activation Protein alpha Rabbit Polyclonal Antibody
VE:
1 * 50 µG
Artikel-Nr:
(USBIP4256-34B)
Lieferant:
US Biological
Hersteller-Artikelnummer::
P4256-34B
Lokale Artikelnummer::
USBIP4256-34B
Beschreibung:
Anti-Plasminogen Activator Inhibitor Type 1 Mouse Monoclonal Antibody [clone: 5F70]
VE:
1 * 500 µG
Artikel-Nr:
(USBIP9102-39A)
Lieferant:
US Biological
Hersteller-Artikelnummer::
P9102-39A
Lokale Artikelnummer::
USBIP9102-39A
Beschreibung:
Anti-Activated Protein C Rat Monoclonal Antibody [clone: PC107]
VE:
1 * 100 µG
Artikel-Nr:
(USBIP4256-34K)
Lieferant:
US Biological
Hersteller-Artikelnummer::
P4256-34K
Lokale Artikelnummer::
USBIP4256-34K
Beschreibung:
Anti-Plasminogen Activator Inhibitor Type I Mouse Monoclonal Antibody [clone: 9B9]
VE:
1 * 100 µl
Lieferant:
Merck
Beschreibung:
Palladium 10% auf Aktivkohle Hydrierkatalysator (oxidierte Form), zur Synthese, nicht reduziert, Sigma-Aldrich®
Artikel-Nr:
(USBIF4208-57H)
Lieferant:
US Biological
Hersteller-Artikelnummer::
F4208-57H
Lokale Artikelnummer::
USBIF4208-57H
Beschreibung:
Anti-Fibroblast Activation Protein alpha Mouse Monoclonal Antibody [clone: 10C243]
VE:
1 * 100 µl
Artikel-Nr:
(USBIP4256-34L)
Lieferant:
US Biological
Hersteller-Artikelnummer::
P4256-34L
Lokale Artikelnummer::
USBIP4256-34L
Beschreibung:
Anti-Plasminogen Activator Inhibitor Type I Mouse Monoclonal Antibody [clone: 9B10]
VE:
1 * 100 µl
Artikel-Nr:
(THARJC690-23)
Lieferant:
THARMAC GmbH
Hersteller-Artikelnummer::
JC690-23
Lokale Artikelnummer::
THARJC690-23
Beschreibung:
Fume hood with activated charcoal filter, Cellstain®
VE:
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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