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Plant+Learning+Activities
Artikel-Nr:
(BOSSBS-1188R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1188R-A350
Lokale Artikelnummer::
BOSSBS-1188R-A350
Beschreibung:
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5399R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5399R-FITC
Lokale Artikelnummer::
BOSSBS-5399R-FITC
Beschreibung:
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3233R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3233R-A647
Lokale Artikelnummer::
BOSSBS-3233R-A647
Beschreibung:
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1761R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1761R-HRP
Lokale Artikelnummer::
BOSSBS-1761R-HRP
Beschreibung:
The MDC gene is one of several Cys-Cys (CC) cytokine genes which are clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by MDC displays chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. It has no chemoattractant activity for eosinophils, neutrophils and resting T lymphocytes and also displays a mild activity for primary activated T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0181R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0181R-CY5
Lokale Artikelnummer::
BOSSBS-0181R-CY5
Beschreibung:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0181R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0181R-CY3
Lokale Artikelnummer::
BOSSBS-0181R-CY3
Beschreibung:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-FITC
Lokale Artikelnummer::
BOSSBS-4985R-FITC
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4820R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4820R-CY5
Lokale Artikelnummer::
BOSSBS-4820R-CY5
Beschreibung:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4820R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4820R-A488
Lokale Artikelnummer::
BOSSBS-4820R-A488
Beschreibung:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2449R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2449R-FITC
Lokale Artikelnummer::
BOSSBS-2449R-FITC
Beschreibung:
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11874R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11874R-CY5
Lokale Artikelnummer::
BOSSBS-11874R-CY5
Beschreibung:
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4819R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4819R-CY5
Lokale Artikelnummer::
BOSSBS-4819R-CY5
Beschreibung:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4819R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4819R-CY5.5
Lokale Artikelnummer::
BOSSBS-4819R-CY5.5
Beschreibung:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4055R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4055R-A680
Lokale Artikelnummer::
BOSSBS-4055R-A680
Beschreibung:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3520R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3520R
Lokale Artikelnummer::
BOSSBS-3520R
Beschreibung:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase mediated apoptosis, PAK2 also interacts with and is activated by HIV1 Nef.
VE:
1 * 100 µl
Lieferant:
ABEBA
Beschreibung:
Active ist eine Reihe spezieller Produkte, die für Berufstätige empfohlen werden, deren Arbeit und tägliche Aufgaben ständige Bewegung sowie stundenlanges Stehen erfordern. Ihr geringes Gewicht trägt dazu bei, die Ermüdung der Beine zu reduzieren. Die Shock-Absorber-Technologie absorbiert Vibrationen und Unebenheiten, schützt vor Verletzungen und sorgt für hohen Komfort - auch bei vielen Arbeitsstunden. Aufgrund der hervorragenden Leistungsparameter ist die Active-Linie ideal für Krankenhäuser, Pflegeheime und die Lebensmittelindustrie.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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