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Artikel-Nr:
(PRSI77-047)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-047
Lokale Artikelnummer::
PRSI77-047
Beschreibung:
The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation.
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(PRSI77-039)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-039
Lokale Artikelnummer::
PRSI77-039
Beschreibung:
The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-gamma) protein, a 15 to 17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation.
VE:
1 * 0,1 mg
New Product
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
5-Iod-α,α,α,α',α',α'-Hexafluor-m-xylol 98%
Artikel-Nr:
(BOSSBS-1736R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1736R-A750
Lokale Artikelnummer::
BOSSBS-1736R-A750
Beschreibung:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyse the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1736R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1736R-A555
Lokale Artikelnummer::
BOSSBS-1736R-A555
Beschreibung:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD147640-100G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD147640-100G
Lokale Artikelnummer::
BLDPBD147640-100G
Beschreibung:
Phenyl-β-D-glucopyranosid 99%
VE:
1 * 100 g
Artikel-Nr:
(BOSSBS-0814R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0814R-A680
Lokale Artikelnummer::
BOSSBS-0814R-A680
Beschreibung:
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
VE:
1 * 100 µl
Artikel-Nr:
(BWRLBS1005)
Lieferant:
Bioworld Technology
Hersteller-Artikelnummer::
BS1005
Lokale Artikelnummer::
BWRLBS1005
Beschreibung:
Synthetic peptide, corresponding to amino acids 700-750 of Human Adducin alpha.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-5617R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5617R-CY7
Lokale Artikelnummer::
BOSSBS-5617R-CY7
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2225R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2225R-CY3
Lokale Artikelnummer::
BOSSBS-2225R-CY3
Beschreibung:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4005R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4005R-CY7
Lokale Artikelnummer::
BOSSBS-4005R-CY7
Beschreibung:
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6976R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6976R-A750
Lokale Artikelnummer::
BOSSBS-6976R-A750
Beschreibung:
Phospholipase C beta 1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Its gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for its gene.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Estradiol 98%
Artikel-Nr:
(AMBI9570)
Lieferant:
AMBION
Hersteller-Artikelnummer::
9570
Lokale Artikelnummer::
AMBI9570
Beschreibung:
γ-(N-Morpholino)propansulfonsäure (MOPS)
VE:
1 * 100 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PRSI91-194)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-194
Lokale Artikelnummer::
PRSI91-194
Beschreibung:
Human Υ-Glutamylcyclotransferase belongs to the Transferases family, specifically the Aminoacyltransferase. Gamma-Glutamylcyclotransferase catalyzes the formation of 5-Pxoproline from Gamma-Glutamyl Dipeptides. It plays an important role in Glutathione Homeostasis. Gamma-Glutamylcyclotransferase induces the release of Cytochrome C from the mitochondria resulting in the induction of apoptosis.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-1063R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1063R-CY5.5
Lokale Artikelnummer::
BOSSBS-1063R-CY5.5
Beschreibung:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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