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Proteine+und+Peptide
Lieferant:
Biotium
Beschreibung:
This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.
Artikel-Nr:
(BOSSBS-2374R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2374R-A647
Lokale Artikelnummer::
BOSSBS-2374R-A647
Beschreibung:
TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11646R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11646R-CY5
Lokale Artikelnummer::
BOSSBS-11646R-CY5
Beschreibung:
Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11646R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11646R-A750
Lokale Artikelnummer::
BOSSBS-11646R-A750
Beschreibung:
Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0018R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0018R-A555
Lokale Artikelnummer::
BOSSBS-0018R-A555
Beschreibung:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3806R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3806R-CY3
Lokale Artikelnummer::
BOSSBS-3806R-CY3
Beschreibung:
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7018R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7018R-CY3
Lokale Artikelnummer::
BOSSBS-7018R-CY3
Beschreibung:
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1860R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1860R-CY7
Lokale Artikelnummer::
BOSSBS-1860R-CY7
Beschreibung:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2789R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2789R-CY5.5
Lokale Artikelnummer::
BOSSBS-2789R-CY5.5
Beschreibung:
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-1 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6739R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6739R-CY3
Lokale Artikelnummer::
BOSSBS-6739R-CY3
Beschreibung:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.Belongs to the Tim17/Tim22/Tim23 family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7018R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7018R-A647
Lokale Artikelnummer::
BOSSBS-7018R-A647
Beschreibung:
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7018R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7018R-FITC
Lokale Artikelnummer::
BOSSBS-7018R-FITC
Beschreibung:
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6211R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6211R-A555
Lokale Artikelnummer::
BOSSBS-6211R-A555
Beschreibung:
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11993R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11993R
Lokale Artikelnummer::
BOSSBS-11993R
Beschreibung:
Changes in the serine/threonine phosphorylation state of a protein in response to various external stimuli can have profound effects on cellular signal transduction, apoptosis and carcinogenesis. The reagents, including phosphorylated protein/peptides, antibodies against the phosphospecific amino acid, are important tools to explore the activation of serine, threonine or tyrosine containing proteins. An aberrant protein phosphorylation is a hallmark of human disease, and the enzymes, particularly protein kinases, which control protein phosphorylation are recognized as a major new drug target family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11018R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11018R-A750
Lokale Artikelnummer::
BOSSBS-11018R-A750
Beschreibung:
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyse the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Multiple transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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