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Pyrazine-2-carboxylic+acid
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Pyrazine-2-carboxylic+acid
Artikel-Nr:
(BOSSBS-11844R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11844R-A647
Lokale Artikelnummer::
BOSSBS-11844R-A647
Beschreibung:
GEFT is a 580 amino acid cytoplasmic protein that is highly expressed in excitable tissues such as brain, heart and muscle, and weakly expressed in small intestine, colon, liver, placenta and lung. GEFT may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. GEFT works as a guanine nucleotide exchange factor for the Rho family of small GTPases and links specifically to G alpha q/11-coupled receptors in Rho A activation. GEFT is an important regulator of processes involved in axon and dendrite formation. Involved in skeletal myogenesis, GEFT seems to be an exchange factor primarily for Rac 1 in neurons. Existing as two alternatively spliced variants, GEFT contains a DH (DBL-homology) domain and a PH domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1322R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1322R-CY5
Lokale Artikelnummer::
BOSSBS-1322R-CY5
Beschreibung:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10757R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10757R-A750
Lokale Artikelnummer::
BOSSBS-10757R-A750
Beschreibung:
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src Signalling pathways. May be involved in neuronal NGF-dependent Ca²⁺ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalisation and recycling of mu-type opioid receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3253R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3253R-A350
Lokale Artikelnummer::
BOSSBS-3253R-A350
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3253R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3253R-HRP
Lokale Artikelnummer::
BOSSBS-3253R-HRP
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8512R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8512R-HRP
Lokale Artikelnummer::
BOSSBS-8512R-HRP
Beschreibung:
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1911R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1911R-A555
Lokale Artikelnummer::
BOSSBS-1911R-A555
Beschreibung:
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1911R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1911R-A350
Lokale Artikelnummer::
BOSSBS-1911R-A350
Beschreibung:
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0076M-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0076M-FITC
Lokale Artikelnummer::
BOSSBS-0076M-FITC
Beschreibung:
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1980R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1980R-A555
Lokale Artikelnummer::
BOSSBS-1980R-A555
Beschreibung:
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9207R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9207R-HRP
Lokale Artikelnummer::
BOSSBS-9207R-HRP
Beschreibung:
Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1980R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1980R-FITC
Lokale Artikelnummer::
BOSSBS-1980R-FITC
Beschreibung:
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6465R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6465R
Lokale Artikelnummer::
BOSSBS-6465R
Beschreibung:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4117R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4117R-CY7
Lokale Artikelnummer::
BOSSBS-4117R-CY7
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4117R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4117R-CY5.5
Lokale Artikelnummer::
BOSSBS-4117R-CY5.5
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9813R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9813R-A680
Lokale Artikelnummer::
BOSSBS-9813R-A680
Beschreibung:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell Signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumour endothelium than in normal tissue endothelium, it is considered to be a candidate for tumour vascular targeting.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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