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Pyrazolo[1,5-a]pyrimidin-7(4H)-one
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Pyrazolo[1,5-a]pyrimidin-7(4H)-one
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
1-[4-(1H-Pyrrol-1-yl)phenyl]-1-ethanone 95%
Artikel-Nr:
(HEATHS4284A)
Lieferant:
HEATHROW
Hersteller-Artikelnummer::
HS4284A
Lokale Artikelnummer::
HEATHS4284A
Beschreibung:
PP, autoklavierbar
VE:
1 * 6 ST
Artikel-Nr:
(BOSSBS-1051R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1051R-A647
Lokale Artikelnummer::
BOSSBS-1051R-A647
Beschreibung:
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7731R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7731R-CY3
Lokale Artikelnummer::
BOSSBS-7731R-CY3
Beschreibung:
Human SUG1 (also known as p45, Rpt6, Cim3 and PSMC5) is a component of the 19S regulatory subunit of the 26S proteosome complex. It is one of the AAA ATPas found in the 19S regulatory complex that is thought to participate in the unfolding of ubiquitinated proteins in an ATP dependent manner. It has also been shown to directly interact with the nucleotide excision repair protein XPB.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0397R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0397R-CY5
Lokale Artikelnummer::
BOSSBS-0397R-CY5
Beschreibung:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
VE:
1 * 100 µl
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-CD337 (NKp30) Mouse Monoclonal Antibody [clone: P30-15] (Brilliant Violet® 711)
Artikel-Nr:
(BOSSBS-9135R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9135R-FITC
Lokale Artikelnummer::
BOSSBS-9135R-FITC
Beschreibung:
Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ASB-17 is a 295 amino acid member of this family. ASB-17 contains one ankyrin repeat and one SOCS box domain. ASB-17 is thought to be a substrate-recognition subunit of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin protein ligase complex. This complex mediates the ubiquitination of target proteins and their subsequent proteasomal degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5828R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5828R-A555
Lokale Artikelnummer::
BOSSBS-5828R-A555
Beschreibung:
Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of nonclassic cadherins. Protocadherin beta 13 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8480R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8480R-FITC
Lokale Artikelnummer::
BOSSBS-8480R-FITC
Beschreibung:
RBMX2 is a 322 amino acid member of the IST3 family that contains one RRM (RNA recognition motif) domain. The RBMX2 gene is intronless, conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice and P.falciparum, and maps to human chromosome Xq25. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions that affect males more frequently as males carry a single X chromosome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2709R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2709R-CY7
Lokale Artikelnummer::
BOSSBS-2709R-CY7
Beschreibung:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
VE:
1 * 100 µl
Lieferant:
Hettich
Beschreibung:
Adapter für 7× konische 15 ml-Röhrchen, zur Verwendung mit Rechteckbecher 521-1324, Tisch-Zentrifuge
Artikel-Nr:
(512-0753)
Lieferant:
Sartorius
Hersteller-Artikelnummer::
VS15TR01
Lokale Artikelnummer::
SARTVS15TR01
Beschreibung:
Vivaspin® Turbo 15 Regenerated Cellulose (RC) membrane, ultrafiltration centrifugal concentrators for protein, DNA, nanoparticle and virus concentration for 4 to 15 ml sample volumes.
VE:
1 * 12 ST
Artikel-Nr:
(BOSSBS-9240R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9240R-CY3
Lokale Artikelnummer::
BOSSBS-9240R-CY3
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF25 (RING finger protein 25), also known as AO7, is a 459 amino acid protein that contains one RWD domain and one RING-type zinc finger. Via its RING-type zinc finger (a common domain that contains a conserved cysteine-rich region and is found in a number of viral and eukaryotic proteins), RNF25 is thought to exhibit E2-dependent E3 ubiquitin-protein ligase activity. Specifically, the RING finger of RNF25 interacts with an E2 ligase and, through this interaction, facilitates the ubiquitination of target proteins. RNF25 may also regulate the transcriptional activity of NF-kappa-B, a protein that plays important roles in cell survival, inflammation response, host defense and proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9152R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9152R-A350
Lokale Artikelnummer::
BOSSBS-9152R-A350
Beschreibung:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM50 (tripartite motif containing 50), also known as TRIM50A or E3 ubiquitin-protein ligase TRIM50, is a 487 amino acid cytoplasmic protein that functions as an E3 ubiquitin-protein ligase. Containing one RING-type zinc finger, a B30.2/SPRY domain and a single B box-type zinc finger, TRIM50 belongs to the TRIM/RBCC family and undergoes post-translational auto-ubiquitination. TRIM50 exists as two alternatively spliced isoforms, designated TRIM50 alpha and TRIM50 beta, and has the ability to form dimers and trimers. The gene encoding TRIM50 maps to human chromosome 7, which houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9402R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9402R-A350
Lokale Artikelnummer::
BOSSBS-9402R-A350
Beschreibung:
CARKD is a 347 amino acid protein that belongs to the YjeF family and exists as three alternatively spliced isoforms. Containing one YjeF C-terminal domain, CARKD is encoded by a gene that maps to human chromosome 13q34. Chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9402R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9402R-CY5.5
Lokale Artikelnummer::
BOSSBS-9402R-CY5.5
Beschreibung:
CARKD is a 347 amino acid protein that belongs to the YjeF family and exists as three alternatively spliced isoforms. Containing one YjeF C-terminal domain, CARKD is encoded by a gene that maps to human chromosome 13q34. Chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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