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Pyridin-N-oxid
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Pyridin-N-oxid
Artikel-Nr:
(BOSSBS-0267R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0267R-A647
Lokale Artikelnummer::
BOSSBS-0267R-A647
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6592R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6592R-CY3
Lokale Artikelnummer::
BOSSBS-6592R-CY3
Beschreibung:
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.Tissue specificity; Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.Sequence similarities; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1074R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1074R-FITC
Lokale Artikelnummer::
BOSSBS-1074R-FITC
Beschreibung:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3831R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3831R-CY3
Lokale Artikelnummer::
BOSSBS-3831R-CY3
Beschreibung:
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
5-Aminomethyl-1H-pyridin-2-one 98%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
5-Brom-2-(piperidin-1-yl)pyridin
Artikel-Nr:
(APOSPC4375-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC4375-5G
Lokale Artikelnummer::
APOSPC4375-5G
Beschreibung:
3-Chlor-2-fluor-5-(trifluormethyl)pyridin
VE:
1 * 5 g
Artikel-Nr:
(APOSPC32877-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC32877-1G
Lokale Artikelnummer::
APOSPC32877-1G
Beschreibung:
1-[6-(3-Fluorophenyl)pyridin-3-yl]ethanone
VE:
1 * 1 g
Artikel-Nr:
(APOSOR470280-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR470280-5G
Lokale Artikelnummer::
APOSOR470280-5G
Beschreibung:
[6-(4-Methoxyphenyl)pyridin-3-yl]methanol
VE:
1 * 5 g
Artikel-Nr:
(APOSPC520161-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC520161-1G
Lokale Artikelnummer::
APOSPC520161-1G
Beschreibung:
7-(Difluoromethyl)pyrazolo[1,5-a]pyridine
VE:
1 * 1 g
Lieferant:
VARTA GERAETEBATTERIE
Beschreibung:
Langlebige Batterien für Kameras und Uhren.
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Fluoro-pyridine-3-sulphonyl chloride
Artikel-Nr:
(BLDPBD165779-25G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD165779-25G
Lokale Artikelnummer::
BLDPBD165779-25G
Beschreibung:
7-Bromo[1,2,4]triazolo[1,5-a]pyridine 97%
VE:
1 * 25 g
Artikel-Nr:
(BOSSBS-10150R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10150R-FITC
Lokale Artikelnummer::
BOSSBS-10150R-FITC
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1548R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1548R-A680
Lokale Artikelnummer::
BOSSBS-1548R-A680
Beschreibung:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. recognises and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2,6-Dichlor-3-(trifluormethyl)pyridin
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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