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Artikel-Nr:
(BOSSBS-9990R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9990R-A680
Lokale Artikelnummer::
BOSSBS-9990R-A680
Beschreibung:
Neural crest cell migration to the third and fourth pharyngeal pouches is a critical step in the structural formation of organs that are affected in DiGeorge syndrome. DGCR6 (DiGeorge syndrome critical region 6) is a nuclear protein that plays a role in neural crest cell migration and is located at the DiGeorge syndrome critical region (DGCR) on chromosome 22. Expressed ubiquitously with highest levels in heart, liver and skeletal muscle, DGCR6 shares high homology with the Drosophila gonadal (gdl) protein and with human Laminin-1, both of which are involved in early tissue development. The gene encoding DGCR6, along with other DGCR genes, is deleted in DiGeorge syndrome; a developmental disorder characterised by improper facial, cardiac and palate formation. Upregulation of DGCR6 is implicated in lung and colon adenocarcinomas, as well as in Burkitt's lymphoma and lymphocytes transformed by EBV. Due to a duplication of the ancestral DGCR6 locus, there are two functional, highly homologous copies of the DGCR6 gene (designated DGCR6 and DGCR6L) on chromosome 22.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10448R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10448R-CY5
Lokale Artikelnummer::
BOSSBS-10448R-CY5
Beschreibung:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15063R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15063R-FITC
Lokale Artikelnummer::
BOSSBS-15063R-FITC
Beschreibung:
C1orf229
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2739R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2739R-HRP
Lokale Artikelnummer::
BOSSBS-2739R-HRP
Beschreibung:
PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1327R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1327R-A647
Lokale Artikelnummer::
BOSSBS-1327R-A647
Beschreibung:
Tenascin, also known as hexabrachion and cytotactin, is an extracellular matrix protein with a spatially and temporally restricted tissue distribution. It is a hexameric, multidomain protein with disulfide linked subunits of 190 to 240 kD, originally characterized as 'myotendinous antigen.' In the embryo it is present in dense mesenchyme surrounding developing epithelia and in developing cartilage and bone. In the adult, tenascin remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0737R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0737R-A680
Lokale Artikelnummer::
BOSSBS-0737R-A680
Beschreibung:
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3489R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3489R-CY5
Lokale Artikelnummer::
BOSSBS-3489R-CY5
Beschreibung:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1990R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1990R-A680
Lokale Artikelnummer::
BOSSBS-1990R-A680
Beschreibung:
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1618R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1618R
Lokale Artikelnummer::
BOSSBS-1618R
Beschreibung:
Anti-MCAM Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8223R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8223R-A750
Lokale Artikelnummer::
BOSSBS-8223R-A750
Beschreibung:
FAM155A.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11800R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11800R-A750
Lokale Artikelnummer::
BOSSBS-11800R-A750
Beschreibung:
Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonpeptide that is involved in the regulation of body fluid osmolality (1-3). AVP mediates its effects through a family of G-protein coupled receptors, the vasopressin receptors type V1a, V2 and V3 (also designated V1b) (1,2). The AVP receptor V1a is responsible for several functions, including blood vessel constriction, liver glycogenolysis and platelet adhesion (3). It is detected as a full length protein and a shorter protein, which results from proteolytic cleavage of its amino terminus (4). The V1a receptor is coupled to Gq/11 protein, which increases the intracellular calcium concentration (3). The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney (5,6). Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterised by the inability of the kidney to concentrate urine in response to AVP (5,7). The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system (7). The AVP receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores (8). AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumours (2).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5447R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5447R-A750
Lokale Artikelnummer::
BOSSBS-5447R-A750
Beschreibung:
When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8391R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8391R-CY5.5
Lokale Artikelnummer::
BOSSBS-8391R-CY5.5
Beschreibung:
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3393R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3393R
Lokale Artikelnummer::
BOSSBS-3393R
Beschreibung:
Anti-SIRT1 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5540R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5540R-HRP
Lokale Artikelnummer::
BOSSBS-5540R-HRP
Beschreibung:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12571R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12571R-CY7
Lokale Artikelnummer::
BOSSBS-12571R-CY7
Beschreibung:
Barrier-to-autointegration factor (BAF) binds non-specifically to double stranded DNA, possibly to play a role in tissue- or cell type-specific gene expression by interacting with different homeodomain transcription factors. BAF compresses chromatin structure and interacts with the LEM domain of nuclear proteins to play a crucial role in membrane recruitment and chromatin decondensation during nuclear assembly. Additionally, retroviruses like HIV-1 incorporate BAF from host cells into preintegration complexes (PICs) to prevent autointegration of retroviral DNA and thereby promote integration of retroviral DNA into the host chromosome.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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