Soluble+gamma-cyclodextrin+polymer+crosslinked+with+epichlorohydr
Artikel-Nr:
(BSBTPB9494)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9494
Lokale Artikelnummer::
BSBTPB9494
Beschreibung:
Rabbit IgG polyclonal antibody for Cystathionine gamma-lyase(CTH) detection. Tested with WB in Human;Mouse;Rat.
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-1935R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1935R-FITC
Lokale Artikelnummer::
BOSSBS-1935R-FITC
Beschreibung:
Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0836R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0836R-FITC
Lokale Artikelnummer::
BOSSBS-0836R-FITC
Beschreibung:
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1935R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1935R-A750
Lokale Artikelnummer::
BOSSBS-1935R-A750
Beschreibung:
Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9881R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9881R-A750
Lokale Artikelnummer::
BOSSBS-9881R-A750
Beschreibung:
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine Signalling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0836R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0836R-A680
Lokale Artikelnummer::
BOSSBS-0836R-A680
Beschreibung:
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1935R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1935R-HRP
Lokale Artikelnummer::
BOSSBS-1935R-HRP
Beschreibung:
Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.
VE:
1 * 100 µl
Lieferant:
Cytiva
Beschreibung:
The microcarrier of choice for cells that are difficult to culture<i> in vitro</i> - particularly for cells with an epithelial-like morphology.
Artikel-Nr:
(PRSI90-539)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-539
Lokale Artikelnummer::
PRSI90-539
Beschreibung:
Stem cell factor (SCF), also known as cKit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilisaion of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/cKit to trigger receptor dimerisaion and signalling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI33-712)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-712
Lokale Artikelnummer::
PRSI33-712
Beschreibung:
The FTL gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. This gene has multiple pseudogenes.<p>Although ferritin light chain has no ferroxidase activity, the light chain may be responsible for the electron transfer across the ferritin protein cage. [Wiki].
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-713)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-713
Lokale Artikelnummer::
PRSI33-713
Beschreibung:
The FTL gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. This gene has multiple pseudogenes.<p>Although ferritin light chain has no ferroxidase activity, the light chain may be responsible for the electron transfer across the ferritin protein cage. [Wiki].
VE:
1 * 100 µG
New Product
Lieferant:
BARNSTEAD THERMOLYNE
Beschreibung:
Die digitalen Inkubationsschüttler mit hoher Kapazität kombinieren kreisende Schüttelbewegungen mit Allzweck-Inkubation und bieten so zusätzliche Vielseitigkeit. Sowohl die gekühlten als auch die Standard-Geräte verfügen über zwei höhenverstellbare Einlegeböden, die zusätzlichen Stauraum bieten. Da der Benutzer zwischen rechtem und linkem Türanschlag wählen kann, kann das Gerät an einer geeigneten Stelle im Labor aufgestellt werden. Die geräumige Edelstahlkammer ermöglicht das Stapeln einer 457×457 mm-Plattform und verdoppelt so die Kapazität des Schüttlers. Anwendungen umfassen Bakteriensuspensionen, Löslichkeitsstudien, Extraktionsverfahren, Färben und Entfärben, Hybridisierungen, Diagnosetests, Waschvorgänge, Proteinexpression und Plasmid-Aufreinigung.
Artikel-Nr:
(PRSI30-376)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-376
Lokale Artikelnummer::
PRSI30-376
Beschreibung:
Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI26-149)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-149
Lokale Artikelnummer::
PRSI26-149
Beschreibung:
IFNGR2 is the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE:
1 * 50 µG
Artikel-Nr:
(BSBTA00449-2)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
A00449-2
Lokale Artikelnummer::
BSBTA00449-2
Beschreibung:
Rabbit IgG polyclonal antibody for Peroxisome proliferator-activated receptor gamma(PPARG) detection. Tested with WB in Human;Mouse;Rat.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI91-024)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-024
Lokale Artikelnummer::
PRSI91-024
Beschreibung:
Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.
VE:
1 * 50 µG
Preis auf Anfrage
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