Sulindac+sulphone-acyl-\u03B2-D-glucuronide
Artikel-Nr:
(BOSSBS-4225R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4225R-CY3
Lokale Artikelnummer::
BOSSBS-4225R-CY3
Beschreibung:
The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups. They have been subdivided into two families, UGT1 and UGT2, based on the evolutionary divergence of their genes. The enzymes of the UGT1A family play an important role in the metabolism of dietary constituents, phenols, and therapeutic drugs, and also the glucuronidation of bilirubin and iodothyronines. The enzymes of the UGT2B family are involved in the metabolism of bile acids, phenol derivatives, catecholestrogens and steroids. Although it is widely recognized that the liver is the major site of glucuronidation, it is now clear that UGT enzymes are also found in extra-hepatic tissues.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI92-096)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-096
Lokale Artikelnummer::
PRSI92-096
Beschreibung:
Acyl-Protein Thioesterase 2 is a cytoplasmic protein that belongs to the AB Hydrolase 2 family. LYPLA2 is a lysophospholipase and hydrolyses fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. LYPLA2 has hydrolase activity that converts Palmitoyl-protein to palmitate and protein. LYPLA2 regulates the multifunctional lysophospholipids by acting on biological membranes. LYPLA2 participates in Glycerophospholipid metabolism pathway, fatty acid metabolic process and lipid metabolic process.
VE:
1 * 50 µG
Lieferant:
MP Biomedicals
Beschreibung:
Coenzyme A (CoA) is an essential metabolic cofactor synthesised from cysteine, pantothenate, and ATP. It plays important roles in many metabolic pathways, including the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example acetyl-CoA, are critical intermediates in many metabolic reactions. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.
Artikel-Nr:
(BOSSBS-10742R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10742R-A680
Lokale Artikelnummer::
BOSSBS-10742R-A680
Beschreibung:
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyses the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI30-881)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-881
Lokale Artikelnummer::
PRSI30-881
Beschreibung:
Carnitine acetyltransferase (CRAT) is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Different subcellular localizations of the CRAT mRNAs are thought to result from alternative splicing of the CRAT gene suggested by the divergent sequences in the 5' region of peroxisomal and mitochondrial CRAT cDNAs and the location of an intron where the sequences diverge.
VE:
1 * 50 µG
Artikel-Nr:
(BSENC-1533-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
C-1533-100
Lokale Artikelnummer::
BSENC-1533-100
Beschreibung:
Peroxisome proliferator-activated receptor gamma (PPARG) is a nuclear hormone receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription (Ref: SWISSPROT).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10742R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10742R-A750
Lokale Artikelnummer::
BOSSBS-10742R-A750
Beschreibung:
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyses the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI25-092)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-092
Lokale Artikelnummer::
PRSI25-092
Beschreibung:
ACADM Is the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Clinical phenotypes are associated with ACADM hereditary deficiency.This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-300)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-300
Lokale Artikelnummer::
PRSI92-300
Beschreibung:
Beta-D-glucuronidase from<i> E. coli</i> is a highly specific enzyme in hydrolysing glucuronides. Beta-D-glucuronidase (GLUase) activity can be measured as the rate of production of fluorescent methylumbelliferone (MU), resulting from the hydrolysis of the substrate 4-methylumbelliferyl- beta -d-glucuronide (MUGLU), which is an effective and rapid method for detection and verification of <i>E. coli </i>in food, water, and environmental samples. High purity recombinant beta-Glucuronidase is used in research, biochemical enzyme assays and <i>in vitro</i> diagnostic analysis, detecting a wide range of drugs such as opioids, benzodiasepines, steroids, cannabinoids, and others.
VE:
1 * 50 µG
Artikel-Nr:
(17-1273-01)
Lieferant:
Cytiva
Hersteller-Artikelnummer::
17-1273-01
Lokale Artikelnummer::
GEHE17-1273-01
Beschreibung:
SOURCE 30S is a synthetic high performance, preparative, chromatography medium, based on a 30 µm monosized, rigid polystyrene/divinyl benzene polymer matrix It is modified with sulphonate (S) strong cation exchange groups.
VE:
1 * 50 mL
Artikel-Nr:
(PRSI25-958)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-958
Lokale Artikelnummer::
PRSI25-958
Beschreibung:
DGAT2L4 is acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. It has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. DGAT2L4 may also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters, however this activity is unclear in vivo.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI30-066)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-066
Lokale Artikelnummer::
PRSI30-066
Beschreibung:
SMPD2 converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
VE:
1 * 100 µG
Artikel-Nr:
(PROONMIAD621)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
NMIAD621
Lokale Artikelnummer::
PROONMIAD621
Beschreibung:
Purity estimate obtained by quantitative NMR against an internal standard of dimethyl sulphone is 84,6 ± 1,5% mass fraction, (95% coverage interval). Supporting evidence is provided by HPLC with UV detection, Karl Fischer analysis and theromogravimetric analysis.
VE:
1 * 1 mg
Lieferant:
MP Biomedicals
Beschreibung:
Coenzyme A is an essential cofactor in enzymatic acetyl transfer reactions. The principal biologically active forms of pantothenic acid are coenzyme A (CoA) and acyl carrier protein (ACP). In CoA, the business center of the molecule is the pantothenic acid metabolite 4'-phosphopantetheine. Coenzyme A is comprised of 4'-phosphopantetheine linked by an anhydride bond to the nucloetide adenosine 5'-monophosphate. 4'-Phosphopantetheine itself is comprised of pantothenic acid linked at one end, via an amide bond, to beta-mercaptoethylamine, derived from L-cysteine, and at the other end to a phosphate group. The sulfhydryl group of 4'-phosphopantetheine, which is the business end of the coenzyme, forms thioesters with acyl groups producing acyl-CoA derivatives, including acetyl-CoA.
Coenzyme A facilitates removal of lipid peroxides by increasing mobilization of fatty acids, and promote repair of plasma membranes by activating phospholipid synthesis.
Artikel-Nr:
(ROCKABTS-100)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
ABTS-100
Lokale Artikelnummer::
ROCKABTS-100
Beschreibung:
ABTS ELISA Peroxidase Substrate (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) is a chromogenic substrate use to visualize reactivity of certain enzymes, particularly in immunosorbent assays. ABTS ELISA Peroxidase Substrate is commonly used with peroxidases, but is amenable to many other enzymes. In the presence of active enzyme, the substrate becomes a soluble green product detectable at 405nm.
VE:
1 * 100 mL
Artikel-Nr:
(BOSSBS-5018R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5018R-CY3
Lokale Artikelnummer::
BOSSBS-5018R-CY3
Beschreibung:
ACADVL (acyl-Coenzyme A dehydrogenase, very long chain) catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. It is specific to esters of long-chain and very long chain fatty acids such as palmitoyl-CoA and stearoyl-CoA. Deficiencies in ACADVL are associated with reduced myocardial fatty acid beta-oxidation and cardiomyopathy.
VE:
1 * 100 µl
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