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Tris(2,2,2-trifluoroethyl)+Phosphate
Artikel-Nr:
(BOSSBS-12550R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12550R-CY3
Lokale Artikelnummer::
BOSSBS-12550R-CY3
Beschreibung:
Mitochondrial ATP synthases (ATPases) transduce the energy contained in membrane electrochemical proton gradients into the energy required for synthesis of high-energy phosphate bonds. ATPases contain two linked complexes: F1, the hydrophilic catalytic core; and F0, the membrane-embedded protein channel. F1 consists of three Alpha chains and three Beta chains, which are weakly homologous, as well as one Gamma chain, one Delta chain and one Gamma chain. F0 consists of three subunits: a, b and c. A mitochondrial F1-ATPase inhibitor protein, ATPIF1 (ATPase inhibitory factor 1), also known as IP, IF1, ATPI or ATPIP (ATPase inhibitor protein), binds to the C-terminal region of a Beta subunit of the F1-ATPase at low pH values and, via interference of the Beta and Gamma subunit interaction, ATPIF1 regulates the activity of the F1F0-ATPase. This reversible ATPIF1 binding to F1F0-ATPase also occurs on the surface of endothelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2125R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2125R-HRP
Lokale Artikelnummer::
BOSSBS-2125R-HRP
Beschreibung:
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
VE:
1 * 100 µl
Artikel-Nr:
(PHBLPB97801-1-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PB97801-1-1G
Lokale Artikelnummer::
PHBLPB97801-1-1G
Beschreibung:
[1-(2,2,2-TRIFLUOROETHYL)INDAZOL-5-YL]ME 1 * 1 g
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-2125R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2125R-A680
Lokale Artikelnummer::
BOSSBS-2125R-A680
Beschreibung:
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalised to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalised proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2125R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2125R-A647
Lokale Artikelnummer::
BOSSBS-2125R-A647
Beschreibung:
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12550R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12550R-CY7
Lokale Artikelnummer::
BOSSBS-12550R-CY7
Beschreibung:
Mitochondrial ATP synthases (ATPases) transduce the energy contained in membrane electrochemical proton gradients into the energy required for synthesis of high-energy phosphate bonds. ATPases contain two linked complexes: F1, the hydrophilic catalytic core; and F0, the membrane-embedded protein channel. F1 consists of three Alpha chains and three Beta chains, which are weakly homologous, as well as one Gamma chain, one Delta chain and one Gamma chain. F0 consists of three subunits: a, b and c. A mitochondrial F1-ATPase inhibitor protein, ATPIF1 (ATPase inhibitory factor 1), also known as IP, IF1, ATPI or ATPIP (ATPase inhibitor protein), binds to the C-terminal region of a Beta subunit of the F1-ATPase at low pH values and, via interference of the Beta and Gamma subunit interaction, ATPIF1 regulates the activity of the F1F0-ATPase. This reversible ATPIF1 binding to F1F0-ATPase also occurs on the surface of endothelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(APOSOR1014926-250)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR1014926-250
Lokale Artikelnummer::
APOSOR1014926-250
Beschreibung:
Sodium ((2R,3S,5R)-3-Hydroxy-5-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Tetrahydrofuran-2-Yl)Methyl Phosphate 250mg pack 1 * 250 mg
VE:
1 * 250 mg
New Product
Artikel-Nr:
(PRSI4613)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4613
Lokale Artikelnummer::
PRSI4613
Beschreibung:
GPAT1 Antibody: Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
VE:
1 * 100 µG
Artikel-Nr:
(AMBDA104389-250MG)
Lieferant:
AMBEED
Hersteller-Artikelnummer::
A104389-250MG
Lokale Artikelnummer::
AMBDA104389-250MG
Beschreibung:
2-AMINO-N-(2,2,2-TRIFLUOROETHYL)ACETAMID 1 * 0,25 g
VE:
1 * 0,25 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-1712R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1712R-CY3
Lokale Artikelnummer::
BOSSBS-1712R-CY3
Beschreibung:
Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The cytokeratins are encoded by a family encompassing 30 genes. Among them, 20 are epithelial genes and the remaining 10 are specific for trichocytes.
In the cytoplasm, the keratin filaments conform a complex network which extends from the surface of the nucleus to the cell membrane. Numerous accessory proteins are involved in the genesis and maintenance of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm and cellular communication mechanisms. Apart from the relatively static functions provided in terms of supporting the nucleus and providing tensile strength to the cell, the cytokeratin networks undergo rapid phosphate exchanges mediated depolymerization, with important implications in the more dynamic cellular processes such as mitosis and post-mitotic period, cell movement and differentiation. Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying connective tissue connection.
VE:
1 * 100 µl
Artikel-Nr:
(PHBLPBZ7131-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBZ7131-1G
Lokale Artikelnummer::
PHBLPBZ7131-1G
Beschreibung:
2,4-DICHLORO-6-(2,2,2-TRIFLUOROETHYL)THI 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PHBLPBV0421-1G)
Lieferant:
PHARMABLOCK
Hersteller-Artikelnummer::
PBV0421-1G
Lokale Artikelnummer::
PHBLPBV0421-1G
Beschreibung:
6-(2,2,2-TRIFLUOROETHYL)-1H-THIENO[2,3-D 1 * 1 g
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(COBBOT-0333-100G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
OT-0333-100G
Lokale Artikelnummer::
COBBOT-0333-100G
Beschreibung:
2,2,2-TRIFLUOROETHYL TOSYLATE FW254.2 1 * 100 g
VE:
1 * 100 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(MSPP2107-3-18-500G)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
2107-3-18-500G
Lokale Artikelnummer::
MSPP2107-3-18-500G
Beschreibung:
Bis(2,2,2-trifluoroethyl)ether 1 * 500 g
VE:
1 * 500 g
This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-13386R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13386R-HRP
Lokale Artikelnummer::
BOSSBS-13386R-HRP
Beschreibung:
Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12550R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12550R-A350
Lokale Artikelnummer::
BOSSBS-12550R-A350
Beschreibung:
Mitochondrial ATP synthases (ATPases) transduce the energy contained in membrane electrochemical proton gradients into the energy required for synthesis of high-energy phosphate bonds. ATPases contain two linked complexes: F1, the hydrophilic catalytic core; and F0, the membrane-embedded protein channel. F1 consists of three Alpha chains and three Beta chains, which are weakly homologous, as well as one Gamma chain, one Delta chain and one Gamma chain. F0 consists of three subunits: a, b and c. A mitochondrial F1-ATPase inhibitor protein, ATPIF1 (ATPase inhibitory factor 1), also known as IP, IF1, ATPI or ATPIP (ATPase inhibitor protein), binds to the C-terminal region of a Beta subunit of the F1-ATPase at low pH values and, via interference of the Beta and Gamma subunit interaction, ATPIF1 regulates the activity of the F1F0-ATPase. This reversible ATPIF1 binding to F1F0-ATPase also occurs on the surface of endothelial cells.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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