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Ethyl+2-(4-Cyanophenyl)-2,2-difluoroacetate
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Ethyl+2-(4-Cyanophenyl)-2,2-difluoroacetate
Artikel-Nr:
(BOSSBS-3303R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3303R-A750
Lokale Artikelnummer::
BOSSBS-3303R-A750
Beschreibung:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukaemia gene, results in chronic myeloproliferative disorder with eosinophilia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3234R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3234R-CY5
Lokale Artikelnummer::
BOSSBS-3234R-CY5
Beschreibung:
Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3236R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3236R-HRP
Lokale Artikelnummer::
BOSSBS-3236R-HRP
Beschreibung:
Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3234R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3234R-CY7
Lokale Artikelnummer::
BOSSBS-3234R-CY7
Beschreibung:
Nuclear factor kappa B (NFkB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NFkB mediates the expression of a great variety of genes in response to extracellular stimuli including IL1, TNF alpha, and bacterial product LPS. NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. IKKa is expressed in variety of human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10662R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10662R-A680
Lokale Artikelnummer::
BOSSBS-10662R-A680
Beschreibung:
Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP Signalling cascade. Required for GDF2/BMP9 Signalling through SMAD1 in endothelial cells and modulates TGF-beta1 Signalling through SMAD3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0351R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0351R-A350
Lokale Artikelnummer::
BOSSBS-0351R-A350
Beschreibung:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4135R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4135R-A647
Lokale Artikelnummer::
BOSSBS-4135R-A647
Beschreibung:
TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
2-Naphthaldehyd ≥98%
Artikel-Nr:
(BOSSBS-3582R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3582R
Lokale Artikelnummer::
BOSSBS-3582R
Beschreibung:
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0351R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0351R-HRP
Lokale Artikelnummer::
BOSSBS-0351R-HRP
Beschreibung:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0351R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0351R-A647
Lokale Artikelnummer::
BOSSBS-0351R-A647
Beschreibung:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4117R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4117R-A647
Lokale Artikelnummer::
BOSSBS-4117R-A647
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4117R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4117R-A555
Lokale Artikelnummer::
BOSSBS-4117R-A555
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1157R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1157R-CY7
Lokale Artikelnummer::
BOSSBS-1157R-CY7
Beschreibung:
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1157R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1157R-A350
Lokale Artikelnummer::
BOSSBS-1157R-A350
Beschreibung:
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1157R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1157R-A555
Lokale Artikelnummer::
BOSSBS-1157R-A555
Beschreibung:
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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