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cis-1,2-Cyclopentandiol
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cis-1,2-Cyclopentandiol
Artikel-Nr:
(BOSSBS-11512R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11512R-CY5
Lokale Artikelnummer::
BOSSBS-11512R-CY5
Beschreibung:
Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS genes map to multiple loci and encode fourteen proteins, BBS1-BBS14. Many BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS10 (Bardet-Biedl syndrome 10), also known as chromosome 12 open reading fame 58, C12orf58 or FLJ23560, is a novel 723 amino acid protein belonging to the TCP-1 chaperonin family. BBS10 localizes to the basal body of primary cilium and assists in protein folding upon ATP hydrolysis. Inhibition of BBS10 has been found to impair ciliogenesis, activate the glycogen synthase kinase 3 pathway and cause peroxisome proliferator-activated receptor nuclear accumulation. The gene encoding BBS10 contains two exons and maps to human chromosome 12q21.2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12332R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12332R-A750
Lokale Artikelnummer::
BOSSBS-12332R-A750
Beschreibung:
Dyrk is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dryk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Dyrk1A is a candidate gene that may be involved in Downs syndrome, and it has been found to be somewhat overexpressed in Downs syndrome. Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus. Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland. The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11769R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11769R
Lokale Artikelnummer::
BOSSBS-11769R
Beschreibung:
The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11769R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11769R-CY7
Lokale Artikelnummer::
BOSSBS-11769R-CY7
Beschreibung:
The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12332R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12332R-CY3
Lokale Artikelnummer::
BOSSBS-12332R-CY3
Beschreibung:
Dyrk is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis (1–3). Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation (1). Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases (4). Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dryk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions (4). Dyrk1A is a candidate gene that may be involved in Downs syndrome, and it has been found to be somewhat overexpressed in Downs syndrome (1,5). Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus (4). Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland (1). The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively (4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11461R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11461R
Lokale Artikelnummer::
BOSSBS-11461R
Beschreibung:
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).
VE:
1 * 100 µl
Artikel-Nr:
(EHERYA12370100ME)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
YA12370100ME
Lokale Artikelnummer::
EHERYA12370100ME
Beschreibung:
Organic Standard, 1,2-Dichlorbenzol-[D4] 2.000 µg/ml in Methanol, Packung: Glasflasche
VE:
1 * 1 mL
Lieferant:
VARIAN
Beschreibung:
Vac Elut™ SPS 24 Vakuumkammer (mit 12×75-mm-Sammelgestell), Für: 12×75-mm-Röhrchen
Artikel-Nr:
(USBI041793-BIOTIN)
Lieferant:
US Biological
Hersteller-Artikelnummer::
041793-BIOTIN
Lokale Artikelnummer::
USBI041793-BIOTIN
Beschreibung:
Anti-SLC12A6 Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(HONCR1054-25MG)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
R1054-25MG
Lokale Artikelnummer::
HONCR1054-25MG
Beschreibung:
Organic Standard, (±)-3-Chloro-1,2-propane-1,1,2,3,3-d₅-diol, Packung: Glass Bottle
VE:
1 * 25 mg
Artikel-Nr:
(REST30281)
Lieferant:
Restek
Hersteller-Artikelnummer::
30281
Lokale Artikelnummer::
REST30281
Beschreibung:
Organic Standard, 1,2-Dichloropropane, 1 ml/ampoule
VE:
1 * 1 mL
Artikel-Nr:
(KRAF05761.7020)
Lieferant:
Bernd Kraft
Hersteller-Artikelnummer::
05761.7020
Lokale Artikelnummer::
KRAF05761.7020
Beschreibung:
Schwefelsäure 6 mol/l (12 N) in wässriger Lösung
VE:
1 * 20 L
Lieferant:
HERAEUS
Beschreibung:
Rotor cover for 12×1,5/2,0 ml tube rotor for microcentrifuge mySPIN™ 6 + 12
Artikel-Nr:
(BOSSBS-12219R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12219R-A488
Lokale Artikelnummer::
BOSSBS-12219R-A488
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF426 (Zinc finger protein 426), also known as MGC2663, is a 554 amino acid protein that is thought to be involved in transcriptional regulation. Localized to the nucleus, ZNF426 contains one KRAB domain and 12 C2H2-type zinc fingers through which it may convey DNA, RNA and protein binding capabilities. Specifically, ZNF426 may interact with the viral protein KSHV ORF 50 and, through this interaction, may activate viral gene transcription.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9084R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9084R-FITC
Lokale Artikelnummer::
BOSSBS-9084R-FITC
Beschreibung:
Belonging to the F-box family of proteins, FBXO35 (F-box only protein 35), also designated F-box and WD-40 domain-containing protein 12 (FBXW12 or FBXO12), is a 464 amino acid protein that contains one C-terminal F-box domain. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein)-type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular mechanisms, including the cell cycle, the immune response, signaling cascades and developmental processes. They function by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO35 can directly interact with Skp1 p19 and CUL-1. FBXO35 is ubiquitously expressed at low levels in most human tissues.
VE:
1 * 100 µl
Lieferant:
BURKLE
Beschreibung:
Made from PP, white.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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