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3-(Difluoromethyl)benzoic+acid
Artikel-Nr:
(BOSSBS-13103R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13103R
Lokale Artikelnummer::
BOSSBS-13103R
Beschreibung:
Anti-ERGIC3 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6905R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6905R-HRP
Lokale Artikelnummer::
BOSSBS-6905R-HRP
Beschreibung:
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7817R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7817R-CY5
Lokale Artikelnummer::
BOSSBS-7817R-CY5
Beschreibung:
Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer 2 labile 4Fe-4S clusters to target apoproteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7744R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7744R-A555
Lokale Artikelnummer::
BOSSBS-7744R-A555
Beschreibung:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8527R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8527R-A555
Lokale Artikelnummer::
BOSSBS-8527R-A555
Beschreibung:
The Vang family of proteins are integral membrane proteins that are homologues of the Drosophila tissue polarity gene strabismus. The gene encoding for Van Gogh-like protein 1 (Vangl1), also designated Strabismus 2 (STB2), localizes to human chromosome 1p11-p13.1. Van Gogh-like protein 2 (Vangl2), also designated Strabismus 1 (STB1), localizes to chromosome 1q22-q23. Vangl1 is expressed primarily in testis and ovary, but is also expressed in gastric and pancreatic cancer. Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in regulating convergent extension (CE) movements during embryogenesis. Vangl1 and Vangl2 are both downregulated in several cancer cell lines and primary tumors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7896R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7896R-A350
Lokale Artikelnummer::
BOSSBS-7896R-A350
Beschreibung:
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7991R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7991R-CY3
Lokale Artikelnummer::
BOSSBS-7991R-CY3
Beschreibung:
May play a role in tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7750R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7750R-A555
Lokale Artikelnummer::
BOSSBS-7750R-A555
Beschreibung:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5357R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5357R-FITC
Lokale Artikelnummer::
BOSSBS-5357R-FITC
Beschreibung:
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13122R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13122R
Lokale Artikelnummer::
BOSSBS-13122R
Beschreibung:
Anti-EXOSC7 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12261R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12261R-FITC
Lokale Artikelnummer::
BOSSBS-12261R-FITC
Beschreibung:
RTF1 is the the major histocompatibility complex (MHC) in the rat which contains genes that code for two class II histocompatibility antigens. RT1-B is an antigen of the RT1 complex. It is a protein dimer consisting of an alpha and beta glycoprotein chain and is homologous to I-A and I-E genes, respectively, in the H-2 complex of the mouse. MHC Class II antigens are useful in studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these also stain stromal cells in the thymus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11366R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11366R-CY3
Lokale Artikelnummer::
BOSSBS-11366R-CY3
Beschreibung:
In all vertebrates, SV2 proteins are abundant, hydrophobic, membrane glycoproteins that are expressed as two major isoforms, SV2A and SV2B, and one minor isoform, SV2C. SV2 proteins are differentially expressed in the brain and are present on all synaptic vesicles, independent of transmitter type. SV2A is abundantly expressed in the subcortex, specifically in the synaptic vesicles of all presynaptic nerve terminals, and also in most neuroendocrine secretory granules. SV2B displays a more restricted pattern of expression in that it is only present on a small subset of synapses in the hippocampus and cortex. SV2A and SV2B are funtionally redundant and are required for maintaining normal brain function in vertebrates. SV2A and SV2B mediate synaptic transmission by regulating cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11777R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11777R-A647
Lokale Artikelnummer::
BOSSBS-11777R-A647
Beschreibung:
Zinc finger FYVE domain-containing protein 27 (ZFYVE27), also known as SPG33, is a 411 amino acid member of the FYVE-finger family of proteins. The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, and a majority of these proteins serve as regulators of endocytic membrane trafficking. ZFYVE27, a multi-pass membrane protein, is an endosomal protein that binds to Spastin, a protein that is primarily involved in microtubule dynamics and severing, vesicular trafficking and endosomal trafficking. Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), a neurodegenerative disorder, characterized by progressive paralysis of the legs, which is caused by impaired axonal transport. Five isoforms of ZFYVE27 exist as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1712R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1712R-CY5.5
Lokale Artikelnummer::
BOSSBS-1712R-CY5.5
Beschreibung:
Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The cytokeratins are encoded by a family encompassing 30 genes. Among them, 20 are epithelial genes and the remaining 10 are specific for trichocytes.
In the cytoplasm, the keratin filaments conform a complex network which extends from the surface of the nucleus to the cell membrane. Numerous accessory proteins are involved in the genesis and maintenance of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm and cellular communication mechanisms. Apart from the relatively static functions provided in terms of supporting the nucleus and providing tensile strength to the cell, the cytokeratin networks undergo rapid phosphate exchanges mediated depolymerization, with important implications in the more dynamic cellular processes such as mitosis and post-mitotic period, cell movement and differentiation. Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying connective tissue connection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13038R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13038R-A350
Lokale Artikelnummer::
BOSSBS-13038R-A350
Beschreibung:
Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10351R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10351R-CY7
Lokale Artikelnummer::
BOSSBS-10351R-CY7
Beschreibung:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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