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17-DMAG+hydrochloride
Artikel-Nr:
(BOSSBS-4183R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4183R-A750
Lokale Artikelnummer::
BOSSBS-4183R-A750
Beschreibung:
Rabphilin-3AL (rabphilin-3A-like), also known as RPH3AL or NOC2, is a cytoplasmic Rab GTPase effector. It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, but unlike its related protein, rabphilin-3A, rabphilin-3AL does not contain any C2 domains. Rabphilin-3AL is expressed in a variety of tissues, with highest levels found in kidney, skeletal muscle, pancreas, liver, ovary, stomach, heart and thyroid. It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells. Via its RBD domain, rabphilin-3AL is capable of binding Rab 27a and, through this interaction, rabphilin-3AL is recruited to dense-core vesicles. With lower affinity, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain. Through an interaction with Rab 3, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion. Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4183R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4183R-CY5.5
Lokale Artikelnummer::
BOSSBS-4183R-CY5.5
Beschreibung:
Rabphilin-3AL (rabphilin-3A-like), also known as RPH3AL or NOC2, is a cytoplasmic Rab GTPase effector. It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, but unlike its related protein, rabphilin-3A, rabphilin-3AL does not contain any C2 domains. Rabphilin-3AL is expressed in a variety of tissues, with highest levels found in kidney, skeletal muscle, pancreas, liver, ovary, stomach, heart and thyroid. It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells. Via its RBD domain, rabphilin-3AL is capable of binding Rab 27a and, through this interaction, rabphilin-3AL is recruited to dense-core vesicles. With lower affinity, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain. Through an interaction with Rab 3, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion. Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells.
VE:
1 * 100 µl
Lieferant:
SIGMA ALDRICH MICROSCOPY
Beschreibung:
Fluorescein isothiocyanate (FITC) is widely used to attach a fluorescent label to proteins via the amine group. The isothiocyanate group reacts with amino terminal and primary amines in proteins. It has been used for the labeling of proteins including antibodies and lectins. Fluorescein isothiocyanate isomer I has been used for the staining of conidia.
Reagent for the FITC labeling of proteins; Microsequencing of proteins and peptides (HPLC).
Artikel-Nr:
(BOSSBS-4183R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4183R-A555
Lokale Artikelnummer::
BOSSBS-4183R-A555
Beschreibung:
Rabphilin-3AL (rabphilin-3A-like), also known as RPH3AL or NOC2, is a cytoplasmic Rab GTPase effector. It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, but unlike its related protein, rabphilin-3A, rabphilin-3AL does not contain any C2 domains. Rabphilin-3AL is expressed in a variety of tissues, with highest levels found in kidney, skeletal muscle, pancreas, liver, ovary, stomach, heart and thyroid. It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells. Via its RBD domain, rabphilin-3AL is capable of binding Rab 27a and, through this interaction, rabphilin-3AL is recruited to dense-core vesicles. With lower affinity, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain. Through an interaction with Rab 3, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion. Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0039R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0039R-A680
Lokale Artikelnummer::
BOSSBS-0039R-A680
Beschreibung:
The activity dependent neuroprotective protein (ADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0039R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0039R-A350
Lokale Artikelnummer::
BOSSBS-0039R-A350
Beschreibung:
The activity dependent neuroprotective protein (ADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5145R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5145R-A647
Lokale Artikelnummer::
BOSSBS-5145R-A647
Beschreibung:
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8435R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8435R-HRP
Lokale Artikelnummer::
BOSSBS-8435R-HRP
Beschreibung:
BXDC1 is a 306 amino acid protein encoded by the human gene BXDC1. BXDC1 is a nuclear protein that contains one Brix domain. Brix domain containing proteins represent a family of proteins involved in the biogenesis of large ribosomal subunits. The Brix domain is a region with homology to the yeast protein Pitx1 (Ribosome biogenesis protein BRX1). Pitx1 is part of a complex that includes RPF1, RPF2 and SSF1 or SSF2. This complex is required for the biogenesis of the 60S ribosomal subunit.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4280R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4280R-A555
Lokale Artikelnummer::
BOSSBS-4280R-A555
Beschreibung:
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
VE:
1 * 100 µl
Lieferant:
MEMMERT
Beschreibung:
FDA-konforme Software AtmoCONTROL (FDA-Edition). Erfüllt die Anforderungen für den Gebrauch von elektronisch gespeicherten Datensätzen und elektronischen Signaturen, die in der Richtlinie 21 CFR Part 11 der US Food and Drug Administration (FDA) festgelegt sind. Grundlizenz für die Steuerung eines Gerätes. Jeweilige IQ/OQ Dokumente in deutscher und englischer Sprache verfügbar (ohne Aufpreis), HPP1400eco
Lieferant:
VWR Chemicals
Beschreibung:
In zwei Packungsgrößen lieferbar: dreifach verpackte (24er-Packung) und doppelt verpackte (30er-Packung). Die Platten sind in einer Blisterpackung mit 6 Fächern verpackt. Jedes Fach enthält eine Platte, sodass bei jedem Öffnen eines Faches nur eine Platte verwendet werden muss. Verfügbar mit TLHTh-Neutralisator (Tween®, Lecithin, Histidin, Thiosulfat).
Artikel-Nr:
(BOSSBS-7903R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7903R-A647
Lokale Artikelnummer::
BOSSBS-7903R-A647
Beschreibung:
AKAP associated sperm protein (encoded by the gene ROPN1L) is a sperm protein which interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. The Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helical domain of AKAP3, allowing PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5215R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5215R-FITC
Lokale Artikelnummer::
BOSSBS-5215R-FITC
Beschreibung:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9119R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9119R-A750
Lokale Artikelnummer::
BOSSBS-9119R-A750
Beschreibung:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7903R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7903R-FITC
Lokale Artikelnummer::
BOSSBS-7903R-FITC
Beschreibung:
AKAP associated sperm protein (encoded by the gene ROPN1L) is a sperm protein which interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. The Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helical domain of AKAP3, allowing PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. The function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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