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3-(Difluoromethyl)benzoic+acid
Artikel-Nr:
(BOSSBS-15482R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-CY3
Lokale Artikelnummer::
BOSSBS-15482R-CY3
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15482R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-HRP
Lokale Artikelnummer::
BOSSBS-15482R-HRP
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15482R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-A350
Lokale Artikelnummer::
BOSSBS-15482R-A350
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(APOSPC450414-25G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC450414-25G
Lokale Artikelnummer::
APOSPC450414-25G
Beschreibung:
Ethyl 1H,1H,2H,2H-perfluorohexyl carbonate
VE:
1 * 25 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Ethyl-2-amino-4,4,4-trifluoro-3-(trifluoromethyl)butyrate
Artikel-Nr:
(BLDPBD0206-5G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD0206-5G
Lokale Artikelnummer::
BLDPBD0206-5G
Beschreibung:
DL-Phenylglycine ethyl ester hydrochloride 98%
VE:
1 * 5 g
Artikel-Nr:
(APOSOR905479-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR905479-1G
Lokale Artikelnummer::
APOSOR905479-1G
Beschreibung:
(2-Ethyl-1H-imidazol-1-yl)acetic acid 95%
VE:
1 * 1 g
Artikel-Nr:
(APOSOR12933-100MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR12933-100MG
Lokale Artikelnummer::
APOSOR12933-100MG
Beschreibung:
{2-[(4-Chlorophenyl)sulphonyl]ethyl}amine hydrochloride
VE:
1 * 100 mg
Artikel-Nr:
(APOSPC410374-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC410374-1G
Lokale Artikelnummer::
APOSPC410374-1G
Beschreibung:
3-[1'-Ethyl-5-(trifluoromethyl)-1H,1'H-3,4'-bipyrazol-1-yl]propanenitrile
VE:
1 * 1 g
Artikel-Nr:
(APOSPC401039-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC401039-1G
Lokale Artikelnummer::
APOSPC401039-1G
Beschreibung:
Ethyl 2-[[2-cyano-5-(trifluoromethyl)pyridin-3-yl]amino]acetate
VE:
1 * 1 g
Artikel-Nr:
(APOSBIB105-100MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
BIB105-100MG
Lokale Artikelnummer::
APOSBIB105-100MG
Beschreibung:
Reversible biotinylation -Water solubleProtein Isolation -Recover Protein-DNA
VE:
1 * 100 mg
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Benzolsulfonsäure-ethylester 95%
Lieferant:
Merck
Beschreibung:
Ethylacetat, Uvasol® für die Spektroskopie, Supelco®
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxaldehyde
Artikel-Nr:
(APOSOR475090-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR475090-1G
Lokale Artikelnummer::
APOSOR475090-1G
Beschreibung:
Ethyl 3-[[1-(2-bromophenyl)ethylamino]methyl]benzoate hydrochloride
VE:
1 * 1 g
Artikel-Nr:
(APOSOR470034-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR470034-5G
Lokale Artikelnummer::
APOSOR470034-5G
Beschreibung:
Methyl 3-(5-Ethyl-1,2,4-oxadiazol-3-yl)benzoate
VE:
1 * 5 g
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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