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ligase
Artikel-Nr:
(BSBTPB9965)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9965
Lokale Artikelnummer::
BSBTPB9965
Beschreibung:
Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase XIAP(XIAP) detection. Tested with WB in Human;Mouse;Rat.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI28-187)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-187
Lokale Artikelnummer::
PRSI28-187
Beschreibung:
UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4317)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4317
Lokale Artikelnummer::
PRSI4317
Beschreibung:
TRIM25 Antibody: TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4315)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4315
Lokale Artikelnummer::
PRSI4315
Beschreibung:
TRIM25 Antibody: TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5147)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5147
Lokale Artikelnummer::
PRSI5147
Beschreibung:
RNF168 Antibody: RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance. At least three isoforms of RNF168 are known to exist.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5737)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5737
Lokale Artikelnummer::
PRSI5737
Beschreibung:
APC11 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI26-266)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-266
Lokale Artikelnummer::
PRSI26-266
Beschreibung:
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
VE:
1 * 50 µG
Artikel-Nr:
(PRSI29-861)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-861
Lokale Artikelnummer::
PRSI29-861
Beschreibung:
LNX1 is a membrane-bound protein that is involved in signal transduction and protein interactions. LNX1 is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis.This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene.
VE:
1 * 100 µG
Artikel-Nr:
(BSBTPA1492)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PA1492
Lokale Artikelnummer::
BSBTPA1492
Beschreibung:
Rabbit IgG polyclonal antibody for Glutamate--cysteine ligase catalytic subunit(GCLC) detection. Tested with WB, IHC-P in Human; Mouse; Rat.
VE:
1 * 0,1 mg
Artikel-Nr:
(PRSI29-821)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-821
Lokale Artikelnummer::
PRSI29-821
Beschreibung:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2I is a member of the E2 ubiquitin-conjugating enzyme family.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5763)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5763
Lokale Artikelnummer::
PRSI5763
Beschreibung:
RNF8 Antibody: RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.
VE:
1 * 100 µG
Artikel-Nr:
(BSBTPB10039)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB10039
Lokale Artikelnummer::
BSBTPB10039
Beschreibung:
Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase AMFR(AMFR) detection. Tested with WB, IHC-P in Human;Rat.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-182)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-182
Lokale Artikelnummer::
PRSI29-182
Beschreibung:
RNF8 contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins.The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI26-977)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-977
Lokale Artikelnummer::
PRSI26-977
Beschreibung:
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
VE:
1 * 50 µG
Artikel-Nr:
(PRSI29-847)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-847
Lokale Artikelnummer::
PRSI29-847
Beschreibung:
KIAA1333 is a probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
VE:
1 * 50 µG
Artikel-Nr:
(BSBTPB9496)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9496
Lokale Artikelnummer::
BSBTPB9496
Beschreibung:
Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase Itchy homolog(ITCH) detection. Tested with WB in Human.
VE:
1 * 100 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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