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ligase
Artikel-Nr:
(BSBTPB9496)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9496
Lokale Artikelnummer::
BSBTPB9496
Beschreibung:
Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase Itchy homolog(ITCH) detection. Tested with WB in Human.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI25-187)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-187
Lokale Artikelnummer::
PRSI25-187
Beschreibung:
COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
VE:
1 * 50 µG
Artikel-Nr:
(BSBTPA2178)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PA2178
Lokale Artikelnummer::
BSBTPA2178
Beschreibung:
Rabbit IgG polyclonal antibody for E3 SUMO-protein ligase EGR2(EGR2) detection. Tested with WB in Human, Mouse, Rat.
VE:
1 * 0,1 mg
Artikel-Nr:
(PRSI6175)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6175
Lokale Artikelnummer::
PRSI6175
Beschreibung:
N4BP1 Antibody: Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI28-085)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-085
Lokale Artikelnummer::
PRSI28-085
Beschreibung:
ARIH2 might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4315)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4315
Lokale Artikelnummer::
PRSI4315
Beschreibung:
TRIM25 Antibody: TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI49-418)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
49-418
Lokale Artikelnummer::
PRSI49-418
Beschreibung:
Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved proteosomal degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Cullin 7 interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.
VE:
1 * 50 µl
Artikel-Nr:
(PRSI26-752)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-752
Lokale Artikelnummer::
PRSI26-752
Beschreibung:
FBXO39 is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
VE:
1 * 50 µG
Artikel-Nr:
(BSBTPB10082)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB10082
Lokale Artikelnummer::
BSBTPB10082
Beschreibung:
Rabbit IgG polyclonal antibody for E3 SUMO-protein ligase PIAS4(PIAS4) detection. Tested with WB in Human;Mouse;Rat.
VE:
1 * 100 µG
Artikel-Nr:
(BSBTPB9798)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9798
Lokale Artikelnummer::
BSBTPB9798
Beschreibung:
Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase RBX1(RBX1) detection. Tested with WB in Human;Mouse;Rat.
VE:
1 * 100 µG
Artikel-Nr:
(BSBTPA2252)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PA2252
Lokale Artikelnummer::
BSBTPA2252
Beschreibung:
Rabbit IgG polyclonal antibody for E3 SUMO-protein ligase PIAS1(PIAS1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI25-857)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-857
Lokale Artikelnummer::
PRSI25-857
Beschreibung:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE3B is a member of the E3 ubiquitin-conjugating enzyme family. UBE3B may interact with other proteins and play a role in stress response.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family. The encoded protein may interact with other proteins and play a role in stress response. Alternatively spliced transcript variants encoding the same protein isoform have been identified for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI27-794)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-794
Lokale Artikelnummer::
PRSI27-794
Beschreibung:
UBE2N encodes a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-861)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-861
Lokale Artikelnummer::
PRSI29-861
Beschreibung:
LNX1 is a membrane-bound protein that is involved in signal transduction and protein interactions. LNX1 is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis.This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-835)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-835
Lokale Artikelnummer::
PRSI29-835
Beschreibung:
WWP2 is a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. WWP2 contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions.This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-178)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-178
Lokale Artikelnummer::
PRSI92-178
Beschreibung:
UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyses its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
VE:
1 * 50 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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