Sie suchten nach: ligase

Artikel-Nr: (BOSSBS-9249R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9249R-A750

Lokale Artikelnummer:: BOSSBS-9249R-A750

Beschreibung: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9249R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9249R-A555

Lokale Artikelnummer:: BOSSBS-9249R-A555

Beschreibung: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5931R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-5931R-HRP

Lokale Artikelnummer:: BOSSBS-5931R-HRP

Beschreibung: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8474R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8474R-HRP

Lokale Artikelnummer:: BOSSBS-8474R-HRP

Beschreibung: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9240R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9240R-CY5.5

Lokale Artikelnummer:: BOSSBS-9240R-CY5.5

Beschreibung: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF25 (RING finger protein 25), also known as AO7, is a 459 amino acid protein that contains one RWD domain and one RING-type zinc finger. Via its RING-type zinc finger (a common domain that contains a conserved cysteine-rich region and is found in a number of viral and eukaryotic proteins), RNF25 is thought to exhibit E2-dependent E3 ubiquitin-protein ligase activity. Specifically, the RING finger of RNF25 interacts with an E2 ligase and, through this interaction, facilitates the ubiquitination of target proteins. RNF25 may also regulate the transcriptional activity of NF-kappa-B, a protein that plays important roles in cell survival, inflammation response, host defense and proliferation.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9240R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9240R-A647

Lokale Artikelnummer:: BOSSBS-9240R-A647

Beschreibung: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF25 (RING finger protein 25), also known as AO7, is a 459 amino acid protein that contains one RWD domain and one RING-type zinc finger. Via its RING-type zinc finger (a common domain that contains a conserved cysteine-rich region and is found in a number of viral and eukaryotic proteins), RNF25 is thought to exhibit E2-dependent E3 ubiquitin-protein ligase activity. Specifically, the RING finger of RNF25 interacts with an E2 ligase and, through this interaction, facilitates the ubiquitination of target proteins. RNF25 may also regulate the transcriptional activity of NF-kappa-B, a protein that plays important roles in cell survival, inflammation response, host defense and proliferation.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9132R)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9132R

Lokale Artikelnummer:: BOSSBS-9132R

Beschreibung: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9240R-A350)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9240R-A350

Lokale Artikelnummer:: BOSSBS-9240R-A350

Beschreibung: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF25 (RING finger protein 25), also known as AO7, is a 459 amino acid protein that contains one RWD domain and one RING-type zinc finger. Via its RING-type zinc finger (a common domain that contains a conserved cysteine-rich region and is found in a number of viral and eukaryotic proteins), RNF25 is thought to exhibit E2-dependent E3 ubiquitin-protein ligase activity. Specifically, the RING finger of RNF25 interacts with an E2 ligase and, through this interaction, facilitates the ubiquitination of target proteins. RNF25 may also regulate the transcriptional activity of NF-kappa-B, a protein that plays important roles in cell survival, inflammation response, host defense and proliferation.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1394R-A350)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-1394R-A350

Lokale Artikelnummer:: BOSSBS-1394R-A350

Beschreibung: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6757R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6757R-CY7

Lokale Artikelnummer:: BOSSBS-6757R-CY7

Beschreibung: The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6757R-CY3)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6757R-CY3

Lokale Artikelnummer:: BOSSBS-6757R-CY3

Beschreibung: The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9140R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9140R-A750

Lokale Artikelnummer:: BOSSBS-9140R-A750

Beschreibung: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localises to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9140R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9140R-HRP

Lokale Artikelnummer:: BOSSBS-9140R-HRP

Beschreibung: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9290R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9290R-FITC

Lokale Artikelnummer:: BOSSBS-9290R-FITC

Beschreibung: PJA2, also known as E3 ubiquitin-protein ligase praja-2, RNF131 (ring finger protein 131) or Neurodap1, is a 708 amino acid protein that contains one ring-type zinc finger and exists as two alternatively spliced isoforms. Significantly conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, PJA2 shares 52% identity with PJA1, which is involved in protein ubiquitination in brain and may play a role in X-linked mental retardation. Encoded by a gene that maps to human chromosome 5q21.3, PJA2 localizes to both endoplasmic reticulum and Golgi apparatus membranes. Participating in E2-dependent, E3 ubiquitin-protein ligase activity, PJA2 binds to a variety of E2s and interacts with ubiquitin-conjugating enzymes, such as UBE2D2, in vitro.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8393R)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8393R

Lokale Artikelnummer:: BOSSBS-8393R

Beschreibung: F box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F box proteins have been shown to be critical for the ubiquitin mediated degradation of cellular regulatory proteins. In fact, F box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F box proteins. A large family of mammalian F box proteins has recently been identified and classified into three groups based on the presence of either the WD 40 repeats, the leucine rich repeats, or the presence or absence of other protein protein interacting domains. The FBXW2 gene product, the second identified member of the F box gene family, contains multiple WD 40 repeats.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-0679R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-0679R-A680

Lokale Artikelnummer:: BOSSBS-0679R-A680

Beschreibung: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

VE: 1 * 100 µl

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