Sie suchten nach: ligase

Artikel-Nr: (BOSSBS-6427R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6427R-CY5

Lokale Artikelnummer:: BOSSBS-6427R-CY5

Beschreibung: Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.Tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.

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Artikel-Nr: (BOSSBS-23085R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-23085R-A750

Lokale Artikelnummer:: BOSSBS-23085R-A750

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9123R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9123R-CY5.5

Lokale Artikelnummer:: BOSSBS-9123R-CY5.5

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9123R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9123R-CY5

Lokale Artikelnummer:: BOSSBS-9123R-CY5

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5931R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-5931R-A750

Lokale Artikelnummer:: BOSSBS-5931R-A750

Beschreibung: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

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Artikel-Nr: (BOSSBS-8054R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8054R-A680

Lokale Artikelnummer:: BOSSBS-8054R-A680

Beschreibung: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

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Artikel-Nr: (BOSSBS-7752R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7752R-FITC

Lokale Artikelnummer:: BOSSBS-7752R-FITC

Beschreibung: KLHL13 (kelch like 13), also known as BKLHD2 (BTB and kelch domain containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate specific adapter of an E3 ubiquitin protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin mediated proteolysis. Via its BTB and C terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL3 ligase.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10059R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-10059R-A647

Lokale Artikelnummer:: BOSSBS-10059R-A647

Beschreibung: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10059R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-10059R-HRP

Lokale Artikelnummer:: BOSSBS-10059R-HRP

Beschreibung: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10059R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-10059R-FITC

Lokale Artikelnummer:: BOSSBS-10059R-FITC

Beschreibung: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-12394R-CY3)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-12394R-CY3

Lokale Artikelnummer:: BOSSBS-12394R-CY3

Beschreibung: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.

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Artikel-Nr: (BOSSBS-6107R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6107R-CY5

Lokale Artikelnummer:: BOSSBS-6107R-CY5

Beschreibung: Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6107R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6107R-CY7

Lokale Artikelnummer:: BOSSBS-6107R-CY7

Beschreibung: Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9121R-CY3)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9121R-CY3

Lokale Artikelnummer:: BOSSBS-9121R-CY3

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9628R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9628R-CY5.5

Lokale Artikelnummer:: BOSSBS-9628R-CY5.5

Beschreibung: C16orf44 is a 616 amino acid protein that contains six Kelch repeats, one BTB/POZ domain and one BTB/Kelch associated (BACK) domain. C16orf44 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, C16orf44 interacts with CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of C16orf44 are expressed.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8383R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8383R-CY5

Lokale Artikelnummer:: BOSSBS-8383R-CY5

Beschreibung: Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (UBE1s), ubiquitin-conjugating enzymes (UBE2s), and ubiquitin-protein ligases (UBE3s). When ubiquitin is activated by a UBE1, it is transferred to the cysteine residue on a UBE2. UBE2 then binds a UBE3, which transfers the ubiquitin from the UBE2 cysteine to a lysine residue on the target protein. Ubiquitin-conjugating enzyme E2 Q1 (UBE2Q1), also known as ubiquitin-protein ligase Q1 or ubiquitin carrier protein Q1, is an 422 amino acid protein belonging to the ubiquitin-conjugating enzyme (UBE2) family. Two named isoforms of UBE2Q1 exist as a result of alternative splicing events.

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