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ligase
Artikel-Nr:
(BOSSBS-9340R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9340R-A350
Lokale Artikelnummer::
BOSSBS-9340R-A350
Beschreibung:
MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13044R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13044R-FITC
Lokale Artikelnummer::
BOSSBS-13044R-FITC
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). DZIP3 (DAZ interacting protein 3, zinc finger), also known as UURF2 or hRUL138, is a 1,208 amino acid protein that localizes to the cytoplasm and contains one RING-type zinc finger. Expressed in a variety of tissues with highest expression in heart, skeletal muscle and kidney, DZIP3 functions as an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme, thereby playing a role in signaling events throughout the cell. Multiple isoforms of DZIP3 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1185R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1185R-A488
Lokale Artikelnummer::
BOSSBS-1185R-A488
Beschreibung:
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8393R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8393R-A350
Lokale Artikelnummer::
BOSSBS-8393R-A350
Beschreibung:
F box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F box proteins have been shown to be critical for the ubiquitin mediated degradation of cellular regulatory proteins. In fact, F box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F box proteins. A large family of mammalian F box proteins has recently been identified and classified into three groups based on the presence of either the WD 40 repeats, the leucine rich repeats, or the presence or absence of other protein protein interacting domains. The FBXW2 gene product, the second identified member of the F box gene family, contains multiple WD 40 repeats.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5931R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5931R-CY3
Lokale Artikelnummer::
BOSSBS-5931R-CY3
Beschreibung:
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9144R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9144R-A647
Lokale Artikelnummer::
BOSSBS-9144R-A647
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1213R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1213R-A647
Lokale Artikelnummer::
BOSSBS-1213R-A647
Beschreibung:
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1905R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1905R-HRP
Lokale Artikelnummer::
BOSSBS-1905R-HRP
Beschreibung:
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7753R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7753R-A647
Lokale Artikelnummer::
BOSSBS-7753R-A647
Beschreibung:
KLHL9 is the substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, KLHL9 controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9340R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9340R-A750
Lokale Artikelnummer::
BOSSBS-9340R-A750
Beschreibung:
MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5935R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5935R-FITC
Lokale Artikelnummer::
BOSSBS-5935R-FITC
Beschreibung:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5935R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5935R-A350
Lokale Artikelnummer::
BOSSBS-5935R-A350
Beschreibung:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7753R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7753R-A350
Lokale Artikelnummer::
BOSSBS-7753R-A350
Beschreibung:
KLHL9 is the substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, KLHL9 controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7752R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7752R-CY5.5
Lokale Artikelnummer::
BOSSBS-7752R-CY5.5
Beschreibung:
KLHL13 (kelch like 13), also known as BKLHD2 (BTB and kelch domain containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate specific adapter of an E3 ubiquitin protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin mediated proteolysis. Via its BTB and C terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL3 ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7752R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7752R-CY3
Lokale Artikelnummer::
BOSSBS-7752R-CY3
Beschreibung:
KLHL13 (kelch like 13), also known as BKLHD2 (BTB and kelch domain containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate specific adapter of an E3 ubiquitin protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin mediated proteolysis. Via its BTB and C terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL3 ligase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6427R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6427R-CY5
Lokale Artikelnummer::
BOSSBS-6427R-CY5
Beschreibung:
Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.Tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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