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ligase
Artikel-Nr:
(BOSSBS-8474R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8474R-A750
Lokale Artikelnummer::
BOSSBS-8474R-A750
Beschreibung:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8474R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8474R-A680
Lokale Artikelnummer::
BOSSBS-8474R-A680
Beschreibung:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9343R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9343R-A680
Lokale Artikelnummer::
BOSSBS-9343R-A680
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH9 (membrane-associated ring finger (C3HC4) 9), also known as RNF179, is a 346 amino acid multi-pass membrane protein that localises to the golgi apparatus and contains one RING-CH-type zinc finger. Expressed ubiquitously, MARCH9 exists as a homodimer and functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to promote the degradation of target proteins, such as CD4 and MHC-I. Multiple isoforms of MARCH9 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7894R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7894R-FITC
Lokale Artikelnummer::
BOSSBS-7894R-FITC
Beschreibung:
CDCA3 (Cell division cycle associated 3) is an F-box-like protein which is required for entry into mitosis. It is associated with SKP1 as part of a SCF (SKP1-cullin-F-box) protein ligase complex, and is required for the ubiquitination and degradation of the CDK1 inhibitory tyrosine kinase WEE1 at G2/M phase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6892R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6892R-CY5
Lokale Artikelnummer::
BOSSBS-6892R-CY5
Beschreibung:
GMCL1L has a possible function in spermatogenesis. It enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport. GMCL1L is also a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6892R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6892R-CY7
Lokale Artikelnummer::
BOSSBS-6892R-CY7
Beschreibung:
GMCL1L has a possible function in spermatogenesis. It enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport. GMCL1L is also a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5470R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5470R
Lokale Artikelnummer::
BOSSBS-5470R
Beschreibung:
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9382R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9382R-A350
Lokale Artikelnummer::
BOSSBS-9382R-A350
Beschreibung:
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9840R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9840R-A680
Lokale Artikelnummer::
BOSSBS-9840R-A680
Beschreibung:
Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9382R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9382R-A555
Lokale Artikelnummer::
BOSSBS-9382R-A555
Beschreibung:
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1185R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1185R-A488
Lokale Artikelnummer::
BOSSBS-1185R-A488
Beschreibung:
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8393R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8393R-A350
Lokale Artikelnummer::
BOSSBS-8393R-A350
Beschreibung:
F box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F box proteins have been shown to be critical for the ubiquitin mediated degradation of cellular regulatory proteins. In fact, F box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F box proteins. A large family of mammalian F box proteins has recently been identified and classified into three groups based on the presence of either the WD 40 repeats, the leucine rich repeats, or the presence or absence of other protein protein interacting domains. The FBXW2 gene product, the second identified member of the F box gene family, contains multiple WD 40 repeats.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13044R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13044R-FITC
Lokale Artikelnummer::
BOSSBS-13044R-FITC
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). DZIP3 (DAZ interacting protein 3, zinc finger), also known as UURF2 or hRUL138, is a 1,208 amino acid protein that localizes to the cytoplasm and contains one RING-type zinc finger. Expressed in a variety of tissues with highest expression in heart, skeletal muscle and kidney, DZIP3 functions as an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme, thereby playing a role in signaling events throughout the cell. Multiple isoforms of DZIP3 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9382R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9382R-A488
Lokale Artikelnummer::
BOSSBS-9382R-A488
Beschreibung:
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5949R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5949R-CY5
Lokale Artikelnummer::
BOSSBS-5949R-CY5
Beschreibung:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0635R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0635R-A750
Lokale Artikelnummer::
BOSSBS-0635R-A750
Beschreibung:
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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