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ligase
Artikel-Nr:
(BOSSBS-7753R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7753R-CY7
Lokale Artikelnummer::
BOSSBS-7753R-CY7
Beschreibung:
KLHL9 is the substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, KLHL9 controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7753R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7753R-CY3
Lokale Artikelnummer::
BOSSBS-7753R-CY3
Beschreibung:
KLHL9 is the substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, KLHL9 controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7784R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7784R-A750
Lokale Artikelnummer::
BOSSBS-7784R-A750
Beschreibung:
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.Tissue specificity: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5174R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5174R-CY7
Lokale Artikelnummer::
BOSSBS-5174R-CY7
Beschreibung:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4090R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4090R
Lokale Artikelnummer::
BOSSBS-4090R
Beschreibung:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5174R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5174R-CY5
Lokale Artikelnummer::
BOSSBS-5174R-CY5
Beschreibung:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9250R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9250R-CY5
Lokale Artikelnummer::
BOSSBS-9250R-CY5
Beschreibung:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. TRAC-1 (T-cell RING activation protein 1), also known as RNF125 (ring finger protein 125) or E3 ubiquitin-protein ligase RNF125, is a 232 amino acid novel E3 ubiquitin ligase that functions as a positive regulator in the T-cell receptor signaling pathway. Expressed predominantly in lymphoid tissues such as spleen, thymus and bone marrow, TRAC-1 has been found to inhibit pathogen-induced cytokine production and down-regulates HIV replication.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9133R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9133R-HRP
Lokale Artikelnummer::
BOSSBS-9133R-HRP
Beschreibung:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9127R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9127R-HRP
Lokale Artikelnummer::
BOSSBS-9127R-HRP
Beschreibung:
Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9126R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9126R-A350
Lokale Artikelnummer::
BOSSBS-9126R-A350
Beschreibung:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9133R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9133R-A750
Lokale Artikelnummer::
BOSSBS-9133R-A750
Beschreibung:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0399R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0399R-A680
Lokale Artikelnummer::
BOSSBS-0399R-A680
Beschreibung:
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9250R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9250R-CY5.5
Lokale Artikelnummer::
BOSSBS-9250R-CY5.5
Beschreibung:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. TRAC-1 (T-cell RING activation protein 1), also known as RNF125 (ring finger protein 125) or E3 ubiquitin-protein ligase RNF125, is a 232 amino acid novel E3 ubiquitin ligase that functions as a positive regulator in the T-cell receptor signaling pathway. Expressed predominantly in lymphoid tissues such as spleen, thymus and bone marrow, TRAC-1 has been found to inhibit pathogen-induced cytokine production and down-regulates HIV replication.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9127R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9127R-A555
Lokale Artikelnummer::
BOSSBS-9127R-A555
Beschreibung:
Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9126R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9126R-A750
Lokale Artikelnummer::
BOSSBS-9126R-A750
Beschreibung:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8471R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8471R-A680
Lokale Artikelnummer::
BOSSBS-8471R-A680
Beschreibung:
Members of the F-box protein family, such as FBXO33, are characterised by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin and F-box proteins act as protein-ubiquitin ligases and mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO33 probably recognises and binds to phosphorylated target proteins.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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