Suche >
ligase
Drucken
Sie suchten nach:
5 491 results were found
ligase
Artikel-Nr:
(BOSSBS-7894R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7894R-HRP
Lokale Artikelnummer::
BOSSBS-7894R-HRP
Beschreibung:
CDCA3 (Cell division cycle associated 3) is an F-box-like protein which is required for entry into mitosis. It is associated with SKP1 as part of a SCF (SKP1-cullin-F-box) protein ligase complex, and is required for the ubiquitination and degradation of the CDK1 inhibitory tyrosine kinase WEE1 at G2/M phase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9089R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9089R-A680
Lokale Artikelnummer::
BOSSBS-9089R-A680
Beschreibung:
Members of the F-box protein family, such as FBXO27, are characterised by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin (CUL1), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8382R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8382R-A647
Lokale Artikelnummer::
BOSSBS-8382R-A647
Beschreibung:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7883R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7883R-A680
Lokale Artikelnummer::
BOSSBS-7883R-A680
Beschreibung:
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8382R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8382R-A680
Lokale Artikelnummer::
BOSSBS-8382R-A680
Beschreibung:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8376R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8376R-A750
Lokale Artikelnummer::
BOSSBS-8376R-A750
Beschreibung:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesised nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9616R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9616R-A680
Lokale Artikelnummer::
BOSSBS-9616R-A680
Beschreibung:
Ubr7 is a 425 amino acid protein that contains one UBR-type zinc finger and one PHD zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr7 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8467R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8467R-FITC
Lokale Artikelnummer::
BOSSBS-8467R-FITC
Beschreibung:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8468R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8468R-CY7
Lokale Artikelnummer::
BOSSBS-8468R-CY7
Beschreibung:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8468R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8468R-A680
Lokale Artikelnummer::
BOSSBS-8468R-A680
Beschreibung:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognises and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1483R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1483R
Lokale Artikelnummer::
BOSSBS-1483R
Beschreibung:
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8468R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8468R-CY5
Lokale Artikelnummer::
BOSSBS-8468R-CY5
Beschreibung:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8468R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8468R-A750
Lokale Artikelnummer::
BOSSBS-8468R-A750
Beschreibung:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognises and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5949R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5949R-A488
Lokale Artikelnummer::
BOSSBS-5949R-A488
Beschreibung:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5949R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5949R-FITC
Lokale Artikelnummer::
BOSSBS-5949R-FITC
Beschreibung:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5949R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5949R-A555
Lokale Artikelnummer::
BOSSBS-5949R-A555
Beschreibung:
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
VE:
1 * 100 µl
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
