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(4-Chloro-3-pyridinyl)methanol
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(4-Chloro-3-pyridinyl)methanol
Artikel-Nr:
(710-0732)
Lieferant:
UVP ULTRA VIOLET PRODUCTS
Hersteller-Artikelnummer::
97-0539-02
Lokale Artikelnummer::
UVPA97-0539-02
Beschreibung:
The innovative and compact design of the ColonyDoc-It™ enables automated, fast and accurate colony counting. The high resolution DSLR colour camera is specifically designed to capture white light and fluorescent marked colonies and a wide array of samples. The sophisticated yet intuitive system offers researchers easy detection and analysis of media. When colony samples require different light sources, the ColonyDoc-It™ enables the easy selection of bright LED lighting. The epi blue light and optional GFP filter enable users to visualise GFP fluorescence detection. The high resolution capabilities allow capture of images down to 0,8 mm. There is no need to adjust camera buttons, since the camera is easily controlled by the software. Connection to a PC/monitor (meeting a minimum specification) is required for full function.
VE:
1 * 1 ST
Artikel-Nr:
(SIAL49667-50MG-F)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
49667-50MG-F
Lokale Artikelnummer::
SIAL49667-50MG-F
Beschreibung:
SPB is an amine-reactive and photoreactive heterobifunctional crosslinking reagent. The photoreactive psoralen group provides much greater covalent insertion yields than phenyl azide-containing compounds, which makes this reagent a superior alternative to typical photoreactive NHS-ester crosslinkers. The psoralen tricyclic planar ring system intercalates into double-stranded, and to a lesser extent, single-stranded, DNA, RNA, PCR products, cDNA or oligonucleotides. It also can be used with agarose gel-purified oligonucleotides because the presence of agarose does not interfere with the coupling reaction. The nucleic acid labeling site of the psoralen group (the 5,6 double bond in thymine residues) does not interfere with subsequent hybridization reactions, creating a highly-sensitive direct labeling alternative to radioactive probes.
VE:
1 * 50 mg
Artikel-Nr:
(BOSSBS-11843R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11843R-CY7
Lokale Artikelnummer::
BOSSBS-11843R-CY7
Beschreibung:
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11103R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11103R-CY7
Lokale Artikelnummer::
BOSSBS-11103R-CY7
Beschreibung:
Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin-1, which is the mammalian homolog of UNC-6 from C. elegans, is largely expressed in the developing nervous system and in mesodermal tissues. Netrin-1 is expressed by the floor plate as either a cell associated protein or in a diffusible form, and it binds to several surface receptor components, including deleted in colorectal cancer (DCC) and neogenin. During embryonic development, netrin-1 diffuses through the neuronal epithelium, where it forms a chemoattractant gradient that directs axonal migration to the ventral midline of the spinal cord. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11843R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11843R-HRP
Lokale Artikelnummer::
BOSSBS-11843R-HRP
Beschreibung:
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11461R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11461R-A350
Lokale Artikelnummer::
BOSSBS-11461R-A350
Beschreibung:
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).
VE:
1 * 100 µl
Artikel-Nr:
(PRSI33-703)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-703
Lokale Artikelnummer::
PRSI33-703
Beschreibung:
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. CD105 has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. It is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
VE:
1 * 100 µG
Lieferant:
MEMMERT
Beschreibung:
Feuchtekammern mit Innenkammer und Gehäuse aus korrosionsfestem Edelstahl für Langzeit-Klimaprüfungen bei konstanter Temperatur und Feuchte. Ideal für die Bereiche Lebensmittelverarbeitung, Kosmetika, Pharmazie, Biotechnologie und Elektronik. Das Gerät besitzt ein Autodiagnosesystem mit Fehleranzeige zur Temperatur- und Feuchteregelung. Die Arbeitskammer wird an allen sechs Seiten aufgeheizt. Zusammen mit der elektronischen Feuchteregelung beugt dies der Kondensatbildung in der Kammer vor. Aus einem externen 2,5-Liter-Behälter wird mit einer selbstansaugenden Pumpe destilliertes Wasser zugeführt. Interner 1024-kB-Protokollspeicher (Ringpuffer) für alle relevanten Daten, Kapazität für etwa drei Monate bei Intervallen von einer Minute. GLP/GMP-Konformität wird durch die USB-Schnittstelle und die „Celsius“ Software für Programmierung und Dokumentation gewährleistet.
Artikel-Nr:
(PRSI90-407)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-407
Lokale Artikelnummer::
PRSI90-407
Beschreibung:
CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumour necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4 + T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-927)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-927
Lokale Artikelnummer::
PRSI91-927
Beschreibung:
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13R alpha1 with low affinity and triggers association of IL4R alpha, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13R alpha2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-558)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-558
Lokale Artikelnummer::
PRSI92-558
Beschreibung:
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumour necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodelling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerisation and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signallling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
VE:
1 * 50 µG
Artikel-Nr:
(MSPP67987)
Lieferant:
MARKET SOURCE PART PROCESS
Hersteller-Artikelnummer::
67987
Lokale Artikelnummer::
MSPP67987
Beschreibung:
[EN]EASICULT COMBI DIAGNOSTIC DIPSLIDES 1 * 10 Tests
VE:
1 * 10 Tests
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PRSI2221)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2221
Lokale Artikelnummer::
PRSI2221
Beschreibung:
BAFF Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kappa B and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-438)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-438
Lokale Artikelnummer::
PRSI92-438
Beschreibung:
Regenerating protein 2 (Reg2) also known as Lithostathine 2, pancreatic thread protein (PTP2) and pancreatic stone protein 2 (PSP2), is a member of the Reg family of proteins. These small, secreted proteins have been implicated in a range of physiological processes including acting as acute phase reactants, lectins, survival/growth factors for insulin-producing pancreatic beta-cells, neural cells, and epithelial cells of the digestive system. Studies also indicate a role for Reg family members in tumour formation and indicate their potential for use as biomarkers of carcinogenesis. Mouse Reg2 is expressed in regenerating islets and normal exocrine pancreas. Reg2 also stimulates the growth of pancreatic beta cells. Mouse Reg2 belongs to the type II subclass of the Reg family and is the only subclass II Reg protein described.
VE:
1 * 50 µG
Lieferant:
IMMUNOLOGIC
Beschreibung:
Paired box (PAX) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The Ser/Thr/ Pro-rich region in the C-terminal portion contains a conserved 100 amino acid transactivating domain. Pax-5 influences the expression of several B-cell-specific genes, such as CD 19 and CD 20. It is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Its mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. It has been found to be important in both B cell and nervous system development.
Artikel-Nr:
(PRSI90-047)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-047
Lokale Artikelnummer::
PRSI90-047
Beschreibung:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
VE:
1 * 10 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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