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BIOSS INC
Artikel-Nr:
(BOSSBS-5550R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5550R-CY5
Lokale Artikelnummer::
BOSSBS-5550R-CY5
Beschreibung:
Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13728R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13728R-A350
Lokale Artikelnummer::
BOSSBS-13728R-A350
Beschreibung:
PCDHGA6 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3754R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3754R-A488
Lokale Artikelnummer::
BOSSBS-3754R-A488
Beschreibung:
Claudin 6 is a multipass transmembrane protein in the Claudin family. Claudin 6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Claudin 6 is also a global marker of definitive endoderm. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9562R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9562R
Lokale Artikelnummer::
BOSSBS-9562R
Beschreibung:
Lysosomal-associated transmembrane protein 4A (LAPTM4A), also known as Golgi 4-transmembrane spanning transporter MTP, is a 233 amino acid protein belonging to the LAPTM5/LAPTM5 transporter family. LAPTM4A is subcellularly localized to the intracytoplasmic membrane and has the potential to reside in intracellular membrane-bound compartments. LAPTM4A is thought to function as a transporter of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of intracellular compartments. LAPTM4A is predicted to have four transmembrane domains, with the C-terminal domain being required for retention of the protein within intracellular membranes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11920R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11920R-A350
Lokale Artikelnummer::
BOSSBS-11920R-A350
Beschreibung:
Homeodomain (HD) genes are helix-turn-helix transcription factors that play key roles in the specification of cell fates. OTP (orthopedia homeobox) is a 325 amino acid nuclear protein belonging to the paired homeobox family and Bicoid subfamily. OTP is expressed in neurons, which give rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV) and arcuate (ARN) nuclei. Containing a homeobox DNA-binding domain and a OAR domain, OTP is suggested to be involved in the differentiation of hypothalamic neuroendocrine cells. At early embryonic stages in mice, the expression of SIM2 is downregulated in the absence of OTP, indicating a potential role for OTP as an upstream regulator of SIM2. OTP is highly conserved in evolution and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8420R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8420R
Lokale Artikelnummer::
BOSSBS-8420R
Beschreibung:
Anti-VAT1L Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5443R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5443R-A555
Lokale Artikelnummer::
BOSSBS-5443R-A555
Beschreibung:
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7762R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7762R-CY5.5
Lokale Artikelnummer::
BOSSBS-7762R-CY5.5
Beschreibung:
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11413R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11413R-CY5
Lokale Artikelnummer::
BOSSBS-11413R-CY5
Beschreibung:
TSKS is a 592 amino acid protein that is highly expressed in human testicular tissue. Low levels of TSKS are detectable in prostate, placenta, fetal liver, thymus, and mammary gland tissues. TSKS is found to be downregulated in cancerous testicular tissue from seminoma, teratocarcinoma, embryonal and Leydig cell tumors concurrently with high expression in neighboring premalignant carcinoma. TSKS protein contains an N-terminal signal peptide, but does not contain a transmembrane region. TSKS has many potential phosphorylation and glycosylation sites and is phosphorylated by soluble recombinant TSSK2 in vitro. It is thought that TSKS likely plays a physiological role in spermatogenesis or spermiogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8177R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8177R-CY7
Lokale Artikelnummer::
BOSSBS-8177R-CY7
Beschreibung:
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11341R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11341R-CY3
Lokale Artikelnummer::
BOSSBS-11341R-CY3
Beschreibung:
Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9735R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9735R-CY5.5
Lokale Artikelnummer::
BOSSBS-9735R-CY5.5
Beschreibung:
The tRNA-splicing endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the heterotetrameric endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. TSEN2 (tRNA-splicing endonuclease subunit Sen2), also known as tRNA-intron endonuclease Sen2, is a 465 amino acid nuclear protein that constitutes one of the two catalytic subunits of the tRNA-splicing endonuclease complex. There are three isoforms of TSEN2 that are produced as a result of alternative splicing events. Isoform 1 seems to carry the active site for 5’-splice site cleavage. Defects in the gene encoding TSEN2 are the cause of pontocerebellar hypoplasia type 2B, which is characterized by progressive microencephaly with epilepsy, extrapyramidal dyskinesia and chorea without spinal cord findings.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6126R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6126R-CY5
Lokale Artikelnummer::
BOSSBS-6126R-CY5
Beschreibung:
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8410R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8410R-CY3
Lokale Artikelnummer::
BOSSBS-8410R-CY3
Beschreibung:
GLCCI1, also known as TSSN1, GIG18 or FAM117C, is a 547 amino acid protein found in thymus and CD4(+)CD8(+) cells during specific stages of spermatogenesis in testis. Subject to phosphorylation, GLCCI1 is encoded by a gene located on human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5997R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5997R-A488
Lokale Artikelnummer::
BOSSBS-5997R-A488
Beschreibung:
Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3796R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3796R-CY5.5
Lokale Artikelnummer::
BOSSBS-3796R-CY5.5
Beschreibung:
Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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