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BIOSS INC
Artikel-Nr:
(BOSSBS-12128R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12128R-A488
Lokale Artikelnummer::
BOSSBS-12128R-A488
Beschreibung:
Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5819R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5819R-FITC
Lokale Artikelnummer::
BOSSBS-5819R-FITC
Beschreibung:
AROS-29 is suggested to have a functional role in protection against oxidative stress. The gene encoding AROS-29 is located on human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs). Key genes for eye color and hair color also map to chromosome 19.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0122R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0122R-A488
Lokale Artikelnummer::
BOSSBS-0122R-A488
Beschreibung:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p5 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8405R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8405R-FITC
Lokale Artikelnummer::
BOSSBS-8405R-FITC
Beschreibung:
GFOD2 is a 385 amino acid secreted protein of the extracellular matrix that belongs to the gfo/idh/mocA family. Existing as two alternatively spliced isoforms, GFOD2 enhances matrix assembly and is encoded by a gene that maps to human chromosome 16q22.1. Chromosome 16 encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1805R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1805R-CY7
Lokale Artikelnummer::
BOSSBS-1805R-CY7
Beschreibung:
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9007R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9007R-HRP
Lokale Artikelnummer::
BOSSBS-9007R-HRP
Beschreibung:
The BTB domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. RCBTB1 (regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1), also known as GLP, CLLD7, CLLL7 or E4.5, is a 531 amino acid protein that localizes to the nucleus and contains two BTB (POZ) domains and six RCC1 repeats. Expressed ubiquitously, RCBTB1 is thought to be involved in cell cycle regulation, specifically via chromatin remodeling. The gene encoding RCBTB1 maps to a region on human chromosome 13 that is frequently deleted in B-cell chronic lymphocytic leukemia, suggesting a possible role for RCBTB1 in tumor suppression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10200R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10200R-CY3
Lokale Artikelnummer::
BOSSBS-10200R-CY3
Beschreibung:
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11511R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11511R-CY5
Lokale Artikelnummer::
BOSSBS-11511R-CY5
Beschreibung:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2650R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2650R
Lokale Artikelnummer::
BOSSBS-2650R
Beschreibung:
Anti-CD207 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2426R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2426R-CY7
Lokale Artikelnummer::
BOSSBS-2426R-CY7
Beschreibung:
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1292R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1292R-FITC
Lokale Artikelnummer::
BOSSBS-1292R-FITC
Beschreibung:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. Belongs to the cytochrome P450 family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6233R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6233R
Lokale Artikelnummer::
BOSSBS-6233R
Beschreibung:
NMT2 catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. several distinct NMTs exist, varying in apparent molecular weight and /or subcellular distribution.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8445R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8445R-A750
Lokale Artikelnummer::
BOSSBS-8445R-A750
Beschreibung:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7526R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7526R-HRP
Lokale Artikelnummer::
BOSSBS-7526R-HRP
Beschreibung:
BTG1 belongs to the BTG family of proteins.FUNCTION: Anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B cell chronic lymphocytic leukemia; translocation t(8;12)(q24;q22) with MYC.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13394R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13394R-A350
Lokale Artikelnummer::
BOSSBS-13394R-A350
Beschreibung:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2724R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2724R-FITC
Lokale Artikelnummer::
BOSSBS-2724R-FITC
Beschreibung:
Cell surface receptor that may play a role in the innate and adaptive immune response.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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