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BIOSS INC
Artikel-Nr:
(BOSSBS-5962R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5962R-HRP
Lokale Artikelnummer::
BOSSBS-5962R-HRP
Beschreibung:
Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13590R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13590R-A555
Lokale Artikelnummer::
BOSSBS-13590R-A555
Beschreibung:
ITPase (inosine triphosphate pyrophosphatase) is also known as putative oncogene protein hlc14-06-p or ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) and is a 194 amino acid protein. ITPase is abundantly expressed in heart, liver, sex glands, thyroid and adrenal gland, and is localized to the cytoplasm in the cell. ITPase catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPase can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPase result in ITPase deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11719R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11719R-CY5
Lokale Artikelnummer::
BOSSBS-11719R-CY5
Beschreibung:
Calcyon is a single transmembrane protein that interacts with D1 dopamine receptors. Dopamine is a neurotransmitter that regulates synaptic transmission involved in learning and memory. D1 receptors, the most abundant dopamine receptor in the central nervous system, appear to modulate the activity of D2 dopamine receptors, mediate various behavioural responses, and regulate neuron growth and differentiation. Calcyon is present in neuronal cell bodies and processes of the cortex and hippocampus, and it is especially abundant in pyramidal neurons. Interaction of Calcyon with D1 receptors results in a release of intracellular calcium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1938R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1938R-A680
Lokale Artikelnummer::
BOSSBS-1938R-A680
Beschreibung:
The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. In mitotic human cells ZW10 resides in a complex with Rod and Zwilch, whereas another ZW10 partner, Zwint-1, is part of a separate complex of structural kinetochore components including Mis12 and Ndc80-Hec1. Zwint-1 is critical for recruiting ZW10 to unattached kinetochores. Depletion from human cells demonstrates that the ZW10 complex is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores. Thus, ZW10 functions as a linker between the core structural elements of the outer kinetochore and components that catalyse generation of the mitotic checkpoint-derived 'stop anaphase' inhibitor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1027R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1027R-A647
Lokale Artikelnummer::
BOSSBS-1027R-A647
Beschreibung:
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6933R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6933R-A488
Lokale Artikelnummer::
BOSSBS-6933R-A488
Beschreibung:
Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12403R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12403R
Lokale Artikelnummer::
BOSSBS-12403R
Beschreibung:
The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1193R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1193R-A680
Lokale Artikelnummer::
BOSSBS-1193R-A680
Beschreibung:
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1460R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1460R-FITC
Lokale Artikelnummer::
BOSSBS-1460R-FITC
Beschreibung:
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9211R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9211R-A555
Lokale Artikelnummer::
BOSSBS-9211R-A555
Beschreibung:
SERPINB10 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in human bone marrow in a search for serpins similar to SerpinB6. SERPINB10 was identified in lymphocytes, and was elevated in chronic myeloid leukemia and chronic myelomonocytic leukemia cells. The monocytic cell lines THP-1 and AML-193 also showed elevated SERPINB10 expression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6239R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6239R-FITC
Lokale Artikelnummer::
BOSSBS-6239R-FITC
Beschreibung:
SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5060R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5060R-CY5.5
Lokale Artikelnummer::
BOSSBS-5060R-CY5.5
Beschreibung:
FADS1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids, linoleic acid and alphanlinolenic acid. It catalyzes the desaturation of dihomo gamma linoleic acid and eicosatetraenoic acid to generate arachidonic acid and eicosapentaenoic acid respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13187R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13187R-A350
Lokale Artikelnummer::
BOSSBS-13187R-A350
Beschreibung:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0022R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0022R-A647
Lokale Artikelnummer::
BOSSBS-0022R-A647
Beschreibung:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12316R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12316R-CY5
Lokale Artikelnummer::
BOSSBS-12316R-CY5
Beschreibung:
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1109R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1109R-A555
Lokale Artikelnummer::
BOSSBS-1109R-A555
Beschreibung:
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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