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BIOSS INC
Artikel-Nr:
(BOSSBS-5309R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5309R-CY3
Lokale Artikelnummer::
BOSSBS-5309R-CY3
Beschreibung:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9265R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9265R-A350
Lokale Artikelnummer::
BOSSBS-9265R-A350
Beschreibung:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF32 (RING finger protein 32), also known as HSD15 or FKSG33, is a 362 amino acid cytoplasmic protein that contains one IQ domain and two RING-type zinc fingers. Highly expressed in testis with lower expression levels in ovary tissue, RNF32 is thought to play a role in spermatogenesis, specifically contributing to the growth and maturation of round spermatids. Six isoforms of RNF32 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5581R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5581R-CY5
Lokale Artikelnummer::
BOSSBS-5581R-CY5
Beschreibung:
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5415R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5415R-A350
Lokale Artikelnummer::
BOSSBS-5415R-A350
Beschreibung:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5597R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5597R-A350
Lokale Artikelnummer::
BOSSBS-5597R-A350
Beschreibung:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5541R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5541R-A350
Lokale Artikelnummer::
BOSSBS-5541R-A350
Beschreibung:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5458R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5458R-CY7
Lokale Artikelnummer::
BOSSBS-5458R-CY7
Beschreibung:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11709R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11709R-A488
Lokale Artikelnummer::
BOSSBS-11709R-A488
Beschreibung:
Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2); infantile onset ascending hereditary spastic paralysis (IAHSP); and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein that is associated with small, punctate membrane structures. Therefore, Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal-like protein (ALS2CL) also modulates Rab 5 activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3338R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3338R
Lokale Artikelnummer::
BOSSBS-3338R
Beschreibung:
Anti-PLCG2 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6589R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6589R
Lokale Artikelnummer::
BOSSBS-6589R
Beschreibung:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8052R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8052R
Lokale Artikelnummer::
BOSSBS-8052R
Beschreibung:
KLHL26 has three named isoforms. The function of KLHL26 remains unknown.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6812R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6812R
Lokale Artikelnummer::
BOSSBS-6812R
Beschreibung:
FMNL1 (Formin-like protein 1) gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cyokinesis, and cell polarity. An alternative splice variant has been described but the full length sequence has not yet been determined. FMNL1 possibly has a role in the control of cell motility and survival of macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7115R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7115R
Lokale Artikelnummer::
BOSSBS-7115R
Beschreibung:
MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11678R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11678R
Lokale Artikelnummer::
BOSSBS-11678R
Beschreibung:
Nuclear pore complexes (NPCs) are the channels for the bi-directional movement of macromolecules between the nucleus and cytoplasm, and contain more than 100 different subunits. Many of them belong to a family called nucleoporins, which are characterized by the presence of O-linked N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nuclear pore complex protein Nup107 (Nucleoporin Nup107) is an essential part of the nuclear pore complex which is composed of Nup133, Nup160, Nup107 and Nup96. Nup107 is active in assembling peripheral proteins into this complex. The protein, located on both the nuclear and cytoplasmic sides of the pore, is important in RNA export.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4778R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4778R-FITC
Lokale Artikelnummer::
BOSSBS-4778R-FITC
Beschreibung:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13521R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13521R-A350
Lokale Artikelnummer::
BOSSBS-13521R-A350
Beschreibung:
G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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