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BIOSS INC
Artikel-Nr:
(BOSSBS-10128R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10128R-CY7
Lokale Artikelnummer::
BOSSBS-10128R-CY7
Beschreibung:
Linker for activation of T cells (LAT) is an integral membrane protein (36 to 38 kD), which plays an important role in linking engagement of the TCR to the biochemical events of T cell activation. LAT antibody stains thymus and peripheral lymphoid tissues such as T cell areas in lymph nodes and spleen. LAT is expressed in T lymphocytes in interstitial spaces, platelets and megakaryocytes. LAT is not expressed in B cells, macrophages, plasma cells, monocytes, epithelial histiocytes and dendritic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8641R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8641R-A750
Lokale Artikelnummer::
BOSSBS-8641R-A750
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHC-type containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13493R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13493R-FITC
Lokale Artikelnummer::
BOSSBS-13493R-FITC
Beschreibung:
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11553R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11553R-HRP
Lokale Artikelnummer::
BOSSBS-11553R-HRP
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15234R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15234R-HRP
Lokale Artikelnummer::
BOSSBS-15234R-HRP
Beschreibung:
Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf195 gene product has been provisionally designated C6orf195 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7013R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7013R-CY3
Lokale Artikelnummer::
BOSSBS-7013R-CY3
Beschreibung:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9034R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9034R-CY5
Lokale Artikelnummer::
BOSSBS-9034R-CY5
Beschreibung:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1188R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1188R-A647
Lokale Artikelnummer::
BOSSBS-1188R-A647
Beschreibung:
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9703R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9703R-A647
Lokale Artikelnummer::
BOSSBS-9703R-A647
Beschreibung:
Hornerin has similar structural features to those of profilaggrin, an essential protein for keratinization of epidermal tissues. Hornerin may play a role in cornification.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5885R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5885R-A750
Lokale Artikelnummer::
BOSSBS-5885R-A750
Beschreibung:
Myosin is a protein which is known to interact with actin in muscle and non-muscle cells. It contains two identical heavy chains and four light chains. Myosin molecules consist of two major regions: tails (rods) and heads. They aggregate into filaments through the tail region and interact with actin and with ATP through the head region. Multiple forms of myosin heavy chains exist for each muscle type-skeletal, cardiac, smooth and non-muscle isomyosin forms exist in different types of skeletal muscle, depending on the physiological function of the muscle. They are designated at type I (slow twitch) and type II (fast twitch).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12315R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12315R-A680
Lokale Artikelnummer::
BOSSBS-12315R-A680
Beschreibung:
GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh Signalling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6299R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6299R-A680
Lokale Artikelnummer::
BOSSBS-6299R-A680
Beschreibung:
PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11741R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11741R-A680
Lokale Artikelnummer::
BOSSBS-11741R-A680
Beschreibung:
The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumours. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10182R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10182R-A750
Lokale Artikelnummer::
BOSSBS-10182R-A750
Beschreibung:
FUT5.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11373R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11373R-A680
Lokale Artikelnummer::
BOSSBS-11373R-A680
Beschreibung:
The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal (Synaptogyrins 1 and 3) and one ubiquitous (Synaptogyrin-2) isoform. Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as Cellugyrin has a tyrosine phosphorylated C-terminal cytoplasmic tail, and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. The SYNGR4 gene encodes for the 234 amino acid protein Synaptogyrin-4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11170R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11170R-A750
Lokale Artikelnummer::
BOSSBS-11170R-A750
Beschreibung:
May be Signalling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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