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BIOSS INC
Artikel-Nr:
(BOSSBS-3127R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3127R-A680
Lokale Artikelnummer::
BOSSBS-3127R-A680
Beschreibung:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4878R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4878R-A488
Lokale Artikelnummer::
BOSSBS-4878R-A488
Beschreibung:
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3022R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3022R-CY5
Lokale Artikelnummer::
BOSSBS-3022R-CY5
Beschreibung:
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), LK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15147R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15147R-CY3
Lokale Artikelnummer::
BOSSBS-15147R-CY3
Beschreibung:
C2orf16 (chromosome 2 open reading frame 16), also known as DKFZp434G118 or DKFZp781D2023, is a 1,984 amino acid protein encoded by a gene that maps to human chromosome 2p23.3. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12872R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12872R-A750
Lokale Artikelnummer::
BOSSBS-12872R-A750
Beschreibung:
Bloom's syndrome is an autosomal recessive disorder characterised by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom's syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom's syndrome patients. One characteristic of Bloom's syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom's cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1803R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1803R
Lokale Artikelnummer::
BOSSBS-1803R
Beschreibung:
Anti-Group I mGLUR Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7049R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7049R-A488
Lokale Artikelnummer::
BOSSBS-7049R-A488
Beschreibung:
May play a role as a mediator of inflammation and angiogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6277R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6277R-FITC
Lokale Artikelnummer::
BOSSBS-6277R-FITC
Beschreibung:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5179R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5179R-CY5.5
Lokale Artikelnummer::
BOSSBS-5179R-CY5.5
Beschreibung:
Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPs). The protein contains a 121 residue extracellular domain, a single transmembrane segment, and 2 tandem intracytoplasmic catalytic domains. The PTP alpha protein is ubiquitously expressed and may play a fundamental role in the physiology of all cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7815R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7815R-A350
Lokale Artikelnummer::
BOSSBS-7815R-A350
Beschreibung:
Required for renal tubular integrity.Tissue specificity: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2044R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2044R-CY5
Lokale Artikelnummer::
BOSSBS-2044R-CY5
Beschreibung:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4081R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4081R-A647
Lokale Artikelnummer::
BOSSBS-4081R-A647
Beschreibung:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3949R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3949R-FITC
Lokale Artikelnummer::
BOSSBS-3949R-FITC
Beschreibung:
Members of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4290R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4290R-A750
Lokale Artikelnummer::
BOSSBS-4290R-A750
Beschreibung:
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12025R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12025R
Lokale Artikelnummer::
BOSSBS-12025R
Beschreibung:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR116 (G protein-coupled receptor 116) is a 1,346 amino acid multi-pass membrane protein that contains one SEA domain, one GPS domain and three Ig-like domains and belongs to the GPR family. Existing as a dilsulfide-liked homodimer at the cell surface, GPR116 exists as multiple alternatively spliced isoforms and is thought to play a role in regulating and maintaining proper acid-base balance throughout the cell.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9083R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9083R-CY5.5
Lokale Artikelnummer::
BOSSBS-9083R-CY5.5
Beschreibung:
FBXW5 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW5 contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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