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Artikel-Nr:
(BOSSBS-5124R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5124R-A350
Lokale Artikelnummer::
BOSSBS-5124R-A350
Beschreibung:
HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms. In Drosophila, the WAVE/ARC pathway may affect the development of the nervous system. HSPC300 is thought to localize to axons of the central nervous system of Drosophila embryos and thus may also be involved in axonogenesis. In addition, HSPC300 is thought to be necessary for synaptic morphogenesis by motoneurons. In mice, the knockout of the WAVE complex leads to learning and memory defects, and it is therefore hypothesized that HSPC300 may also be involved in cognitive functions. Genetic depletion of HSPC300 results in cytoskeletal abnormalities and prevents cytokinesis of cells, suggesting that decreased levels of HSPC300 may be associated with tumor suppression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0677R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0677R-A555
Lokale Artikelnummer::
BOSSBS-0677R-A555
Beschreibung:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4173R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4173R-FITC
Lokale Artikelnummer::
BOSSBS-4173R-FITC
Beschreibung:
Twist2 (Twist homolog 2) is a basic helix-loop-helix (bHLH) transcription factor which acts as a transcriptional repressor. It binds to the E-box consensus sequence 5'-CANNTG-3' and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Efficient DNA binding requires dimerization with another bHLH protein. Twist2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9235R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9235R-CY3
Lokale Artikelnummer::
BOSSBS-9235R-CY3
Beschreibung:
The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila ‘caudal’ gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2 are expressed in the small intestine and colon of fetus and adult. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human Cdx1 gene maps to chromosome 5q31-q33 and encodes a 265-amino acid protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1558R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1558R-FITC
Lokale Artikelnummer::
BOSSBS-1558R-FITC
Beschreibung:
Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1589R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1589R-A350
Lokale Artikelnummer::
BOSSBS-1589R-A350
Beschreibung:
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBSM-0388M-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BSM-0388M-A750
Lokale Artikelnummer::
BOSSBSM-0388M-A750
Beschreibung:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15582R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15582R-FITC
Lokale Artikelnummer::
BOSSBS-15582R-FITC
Beschreibung:
IKB epsilon (Ser22).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15095R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15095R-A680
Lokale Artikelnummer::
BOSSBS-15095R-A680
Beschreibung:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf144 gene product has been provisionally designated C20orf144 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1789R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1789R
Lokale Artikelnummer::
BOSSBS-1789R
Beschreibung:
Anti-IL12A Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1769R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1769R-A750
Lokale Artikelnummer::
BOSSBS-1769R-A750
Beschreibung:
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also Hydrolyse P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1619R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1619R-A555
Lokale Artikelnummer::
BOSSBS-1619R-A555
Beschreibung:
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1564R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1564R-A680
Lokale Artikelnummer::
BOSSBS-1564R-A680
Beschreibung:
The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A4 (ANXA4) belongs to the annexin family of calcium dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane related events along exocytotic and endocytotic pathways. ANXA4 has 45 to 59% identity with other members of its family and shares a similar size and exon intron organization. Isolated from human placenta, ANXA4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANXA4 is almost exclusively expressed in epithelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1175R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1175R-FITC
Lokale Artikelnummer::
BOSSBS-1175R-FITC
Beschreibung:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1538R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1538R
Lokale Artikelnummer::
BOSSBS-1538R
Beschreibung:
Anti-SERPINH1 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6094R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6094R-A750
Lokale Artikelnummer::
BOSSBS-6094R-A750
Beschreibung:
RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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