Sie suchten nach: TONBO BIOSCIENCE

Lieferant: Tonbo Biosciences

Beschreibung: The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

Artikel-Nr: (25-4321-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 25-4321-U100

Lokale Artikelnummer:: TNBO25-4321-U100

Beschreibung: The A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin binds to TNP (trinitrophenol), a hapten not expressed on mouse or human cells. It is used as an isotype control for rat IgG2a antibodies.

VE: 1 * 100 µG

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Artikel-Nr: (35-8070-M002)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 35-8070-M002

Lokale Artikelnummer:: TNBO35-8070-M002

Beschreibung: Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/bovine, human, or mouse IgG

VE: 1 * 2 mg

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Lieferant: Tonbo Biosciences

Beschreibung: The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.

Lieferant: Tonbo Biosciences

Beschreibung: The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

Artikel-Nr: (75-4724-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 75-4724-U100

Lokale Artikelnummer:: TNBO75-4724-U100

Beschreibung: The C1.18.4 immunoglobulin is useful as an isotype-matched control. The C.1.18.4 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2a antibodies.

VE: 1 * 100 µG

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Lieferant: Tonbo Biosciences

Beschreibung: The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.

Artikel-Nr: (40-5874-U500)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 40-5874-U500

Lokale Artikelnummer:: TNBO40-5874-U500

Beschreibung: The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

VE: 1 * 500 µG

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Lieferant: Tonbo Biosciences

Beschreibung: The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognise antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

Artikel-Nr: (40-1276-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 40-1276-U100

Lokale Artikelnummer:: TNBO40-1276-U100

Beschreibung: The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.

VE: 1 * 100 µG

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Artikel-Nr: (50-8033-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 50-8033-U100

Lokale Artikelnummer:: TNBO50-8033-U100

Beschreibung: Goat anti-mouse IgG (H+L), secondary antibody, SureLight® R-Phycoerythrin, 100ug

VE: 1 * 100 µG

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Artikel-Nr: (70-8076-M002)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 70-8076-M002

Lokale Artikelnummer:: TNBO70-8076-M002

Beschreibung: Rabbit anti-Mouse IgG (H&L) - Affinity Pure

VE: 1 * 2 mg

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Artikel-Nr: (75-4301-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 75-4301-U100

Lokale Artikelnummer:: TNBO75-4301-U100

Beschreibung: The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.

VE: 1 * 100 µG

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Artikel-Nr: (35-8058-U500)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 35-8058-U500

Lokale Artikelnummer:: TNBO35-8058-U500

Beschreibung: Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, FITC Conjugate

VE: 1 * 0,5 mg

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Artikel-Nr: (70-0088-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 70-0088-U100

Lokale Artikelnummer:: TNBO70-0088-U100

Beschreibung: The RPA-T8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

VE: 1 * 100 µG

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Artikel-Nr: (92-7770-T100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 92-7770-T100

Lokale Artikelnummer:: TNBO92-7770-T100

Beschreibung: The FITC Mouse Lineage Cocktail contains a combination of pre-diluted antibodies that identify lineage committed cells by flow cytometry and facilitate their exclusion from hematopoietic progenitor cells in mouse bone marrow. The antibodies in the cocktail react with cells from major hematopoietic lineages including T, B and NK cells, monocytes/macrophages, granulocytes and erythrocytes. The Lineage Cocktail contains the following FITC conjugated antibodies: anti-mouse CD3 (17A2), anti-mouse CD11b (M1/70), anti-mouse CD45/B220 (RA3-6B2), anti-mouse Ly-6G (Gr-1) (RB6-8C5) and anti-mouse TER-119 (TER-119). An Isotype Control Cocktail consisting of FITC conjugated isotype-matched control antibodies (Rat IgG2a, kappa; Rat IgG2b, kappa) is also provided in a separate vial.

VE: 1 * 100 Tests

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