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Artikel-Nr:
(BOSSBS-5814R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5814R-CY7
Lokale Artikelnummer::
BOSSBS-5814R-CY7
Beschreibung:
Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30%, but their genomic organization is strikingly similar. Like Prominin 1, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains. Similar to Prominin1 localization, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from adult kidney, and all along the digestive track and other epithelial tissues.Prominin 2 expression is down-regulated in aggressive prostate cancer cell lines and transient transfection of PROML2 expression vectors has been shown to induce apoptosis in cultured prostate cancer cells, suggesting a tumor suppressive role for Prominin 2. Prominin 2 expression is likely to be involved in growth suppression in the prostate, and down-regulation of Prominin 2 may disrupt normal prostatic homeostasis and lead to uncontrolled prostatic growth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1228R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1228R-A680
Lokale Artikelnummer::
BOSSBS-1228R-A680
Beschreibung:
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterised adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11241R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11241R-CY5
Lokale Artikelnummer::
BOSSBS-11241R-CY5
Beschreibung:
Adaptins are heterotetrameric subunits of adaptors, which are complexes involved in the formation of Clathrin-coated pits for vesicle-mediated endocytosis. Clathrin and its associated heterotetrameric protein complexes make up the main protein components of the coat surrounding the cytoplasmic face of coated vesicles. The Adaptin family, comprising a, b, and g classes, is also responsible for the transport of ligand-receptor complexes from plasma membranes and the trans-Golgi network to lysosomes. Two main types of adaptor proteins (APs), AP-1 and AP-2, are found in Clathrin-coated structures located at the Golgi complex and the plasma membrane of mammalian cells, respectively. Adaptor protein complex 2 (AP-2) is composed of two large Adaptins (a1A/AP2A1 and b1/AP2B1), a medium Adaptin (m2/AP-2m1) and a small Adaptin (s2 long/AP2S1). AP-2m1, a 435 amino acid protein, links Clathrin to receptors in coated vesicles.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2835R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2835R-CY5.5
Lokale Artikelnummer::
BOSSBS-2835R-CY5.5
Beschreibung:
The ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11333R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11333R-CY3
Lokale Artikelnummer::
BOSSBS-11333R-CY3
Beschreibung:
Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with Clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of Clathrin binding Adaptin proteins (g and b1 for AP-1, a and b2 for AP-2) and two smaller subunits known as AP50 and AP17. The a and b Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. a-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP-3 (also designated AP180 or F1-20) is a synapse-specific Clathrin assembly protein. The protein CALM (Clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in Clathrin assembly.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1228R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1228R-FITC
Lokale Artikelnummer::
BOSSBS-1228R-FITC
Beschreibung:
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
VE:
1 * 100 µl
Artikel-Nr:
(KRAF21481.0802)
Lieferant:
Bernd Kraft
Hersteller-Artikelnummer::
21481.0802
Lokale Artikelnummer::
KRAF21481.0802
Beschreibung:
Kernechtrot
VE:
1 * 5 g
Artikel-Nr:
(HONCR1364-10MG)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
R1364-10MG
Lokale Artikelnummer::
HONCR1364-10MG
Beschreibung:
Organic Standard, Canthaxanthin (trans), Packung: Glass Bottle
VE:
1 * 10 mg
Lieferant:
VWR Collection
Beschreibung:
Ergonomisches Design ermöglicht zusätzlichen Bedienkomfort für große und kleine Hände, Links- oder Rechtshänder.
Artikel-Nr:
(ICNA0215264825)
Lieferant:
MP Biomedicals
Hersteller-Artikelnummer::
0215264825
Lokale Artikelnummer::
ICNA0215264825
Beschreibung:
This product is soluble in chloroform (10 mg/ml), toluene, methanol. Saturated solutions can be prepared in isopropanol. Insoluble in water.
VE:
1 * 25 g
Artikel-Nr:
(PRSI27-800)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-800
Lokale Artikelnummer::
PRSI27-800
Beschreibung:
ZNF395 is a novel transcription factor shuttling between nucleus and cytoplasm and bind to the specific GCCGGCG, which is an essential cis-element for HD gene expression in neuronal cells. ZNF395 might play a role in transcription of PV genes and in E2-mediated repression.
VE:
1 * 50 µG
Artikel-Nr:
(ERLAAA626A00011A21)
Lieferant:
ERLAB CAPTAIRE
Hersteller-Artikelnummer::
AA626A00011A21
Lokale Artikelnummer::
ERLAAA626A00011A21
Beschreibung:
Die neuen Captair® Smart-Filterhauben ohne Abluftkanal sind mit einer einfachen und innovativen Kommunikationsmethode ausgestattet. Smart Technology, einfache und intuitive Kommunikation per Licht zeigt den Status der Haube an. Ein einfaches Lichtmuster zeigt an, ob der Luftstrom beeinträchtigt ist, ob ein Lüfterausfall vorliegt oder ob ein Filter durchgebrochen ist.
VE:
1 * 1 ST
New Product
Artikel-Nr:
(BOSSBS-6216R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6216R-A750
Lokale Artikelnummer::
BOSSBS-6216R-A750
Beschreibung:
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13345R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13345R
Lokale Artikelnummer::
BOSSBS-13345R
Beschreibung:
The GGA family of proteins (Golgi-localized, g-Adaptin ear-containing, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin. Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multi-domain proteins that bind mannose 6-phosphate receptors (MPRs). GGAs have modular structures with an N-terminal VHS (VPS27, Hrs and STAM) domain followed by a GAT (GGA and Tom1) domain, a connecting hinge segment and a C-terminal GAE (g-Adaptin ear) domain. The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences. The human GGA3 gene maps to chromosome 17 and encodes a 723 amino acid protein that shares 46% sequence identity with GGA1 and 38% with GGA2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6216R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6216R-A680
Lokale Artikelnummer::
BOSSBS-6216R-A680
Beschreibung:
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
VE:
1 * 100 µl
Lieferant:
OMEGA BIO-TEK
Beschreibung:
Das E.Z.N.A.® Stool DNA Kit ermöglicht die schnelle und zuverlässige Isolierung qualitativ hochwertiger Gesamt-DNA aus frischen und gefrorenen Stuhlproben. Bis zu 200 mg Stuhlproben können in weniger als 60 Minuten verarbeitet werden. Das System kombiniert die reversiblen Nukleinsäure-Bindungseigenschaften der HiBind® Matrix mit der Geschwindigkeit und Vielseitigkeit der Zentrifugensäulentechnologie zur Eliminierung von Polysacchariden, Phenolverbindungen und Enzyminhibitoren aus Stuhlproben. Die aufgereinigte DNA eignet sich für PCR, Restriktionsverdauung und Hybridisierungverfahren.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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