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Proteine und Peptide
Artikel-Nr:
(PRSI91-383)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-383
Lokale Artikelnummer::
PRSI91-383
Beschreibung:
Adipocyte Adhesion Molecule (ASAM) is a type I transmembrane protein and member of the CTX family within the immunoglobulin superfamily. ASAM may be involved in the cell-cell adhesion, play an important role in adipocyte differentiation and development of obesity. ASAM can be expressed in the skeletal, heart, colon, spleen, muscle, lung and kidney with high level, and in the peripheral blood leukocytes and liver with low level. The extracellular region of ASAM consists two potential N-linked glycosylation sites, and two immunoglobulin domains, one V-type and one C2-type.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-519)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-519
Lokale Artikelnummer::
PRSI91-519
Beschreibung:
T-Cell Surface Glycoprotein CD8 beta Chain (CD8 Antigen) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 Antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-116)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-116
Lokale Artikelnummer::
PRSI92-116
Beschreibung:
Interleukin-3 (IL-3) is a potent growth promoting cytokine. IL-3 can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its biological function through binding to specific cell surface receptors. The amino acid sequences of this protein among different species share relatively low identity and its activity is highly species-specific. IL-3 has also been shown to possess neurotrophic activity, and is thought to be associated with neurologic disorders.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-530)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-530
Lokale Artikelnummer::
PRSI90-530
Beschreibung:
Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naie CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-609)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-609
Lokale Artikelnummer::
PRSI96-609
Beschreibung:
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI96-071)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-071
Lokale Artikelnummer::
PRSI96-071
Beschreibung:
Human recombinant CADM1 (from HEK293 cells)
VE:
1 * 100 µG
Artikel-Nr:
(PRSI6651P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6651P
Lokale Artikelnummer::
PRSI6651P
Beschreibung:
SFTS Virus HB29 peptide is used for blocking the activity of SFTS Virus HB29 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-086)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-086
Lokale Artikelnummer::
PRSI90-086
Beschreibung:
ANGPTL3 (Angiopoietin-like protein 3) regulates angiogenesis and also directly regulates lipid, glucose, and energy metabolism.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI92-187)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-187
Lokale Artikelnummer::
PRSI92-187
Beschreibung:
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an important role in the apoptotic process, possibly within the modified cytoskeleton.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-926)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-926
Lokale Artikelnummer::
PRSI91-926
Beschreibung:
Glial Cell Line-Derived Neurotrophic Factor Family Receptor alpha-1 (GDNFR alpha1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor alpha subtype which consists of at least four members. GFR alpha1and GFR alpha2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFR alphas released enzymatically from the cell surface by phosphatidylinositol phospholipase C, as well as recombinantly produced soluble GFR alpha1, can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFR alpha1 shares 93% amino acid identity with mouse GFR alpha1.The expression of the various GFR alphas are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFR alphas in mediating the activities of the GDNF family of neurotrophic factors.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-469)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-469
Lokale Artikelnummer::
PRSI91-469
Beschreibung:
Chymotrypsin C (CTRC) is a member of the peptidase S1 family. CTRC is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. CTRC has broad substrate specificity, but prefers tocleave on the carboxyl side of hydrophobic residues. CTRC is expressed primarily in the pancreas, and is secreted into the digestive tract. CTRC plays a protective role in the pancreas by mitigating premature trypsinogen activation through degradation. It has been proposed that CTRC is a key regulator of digestive zymogen activation and is a physiological coactivator of digestive carboxypeptidases proCPA1 and proCPA2. The mutation of CTRC gene encodes the digestive enzyme CTRC contribute to the development of pancreatitis.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-909)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-909
Lokale Artikelnummer::
PRSI91-909
Beschreibung:
PSG2 is a secreted protein that in humans is encoded by the PSG2 gene. It is a member of the human pregnancy-specific glycoproteins (PSGs) family. These proteins are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. PSG2 consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. It has an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3467P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3467P
Lokale Artikelnummer::
PRSI3467P
Beschreibung:
Caspase-7 peptide is used for blocking the activity of caspase-7 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6231P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6231P
Lokale Artikelnummer::
PRSI6231P
Beschreibung:
ZFP219 peptide is used for blocking the activity of ZFP219 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-687)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-687
Lokale Artikelnummer::
PRSI91-687
Beschreibung:
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to the NMDA receptor and this could be a mechanism behind Smith-Magenis syndrome.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5215P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5215P
Lokale Artikelnummer::
PRSI5215P
Beschreibung:
SHOC2 peptide is used for blocking the activity of SHOC2 antibody.
VE:
1 * 50 µG
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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