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Proteine und Peptide
Artikel-Nr:
(PRSI91-243)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-243
Lokale Artikelnummer::
PRSI91-243
Beschreibung:
The enzyme UDP-Glucose 4-Epimerase (GALE) is a homodimeric epimerase found in bacterial, plant and mammalian cells. UDP-Glucose 4-Epimerase performs the final step in the Leloir pathway of Galactose metabolism, it catalyzes two distinct but analogous reactions: the epimerization of UDP-Gglucose to UDP-Galactose and the epimerization of UDP-N-Acetylglucosamine to UDP-N-Acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6631P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6631P
Lokale Artikelnummer::
PRSI6631P
Beschreibung:
EPAC1 peptide is used for blocking the activity of EPAC1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6099P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6099P
Lokale Artikelnummer::
PRSI6099P
Beschreibung:
ZIP10 peptide is used for blocking the activity of ZIP10 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-596)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-596
Lokale Artikelnummer::
PRSI92-596
Beschreibung:
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3665P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3665P
Lokale Artikelnummer::
PRSI3665P
Beschreibung:
BAP31 peptide is used for blocking the activity of BAP31 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4749P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4749P
Lokale Artikelnummer::
PRSI4749P
Beschreibung:
Adenovirus-9 E4 Orf1 peptide is used for blocking the activity of Adenovirus-9 E4 Orf1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3027P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3027P
Lokale Artikelnummer::
PRSI3027P
Beschreibung:
NALP2 peptide is used for blocking the activity of NALP2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-574)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-574
Lokale Artikelnummer::
PRSI92-574
Beschreibung:
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% to 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerisation and heterodimerisation with ErbB2, resulting in cell signallling, heterodimerisation tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signalling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumours. Several anti-cancer drugs use EGFR as target.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-440)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-440
Lokale Artikelnummer::
PRSI90-440
Beschreibung:
CD276 (B7-H3) is a member of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T cell response. B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are known to modulate T cell receptor (TCR)-mediated T cell activation by providing co-signals that are either stimulatory or inhibitory. B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3 is a negative regulator that preferentially affects T(H)1 responses. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. Recently, B7-H3 expression has also been found in a variety of different human cancers, including prostate cancer, clear cell renal cell carcinoma (ccRCC), non-small-cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, ovarian cancer, colorectal cancer (CRC) and urothelial cell carcinoma. B7-H3 was expressed in some human cancers and correlated with poor outcome of cancer patients.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI91-375)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-375
Lokale Artikelnummer::
PRSI91-375
Beschreibung:
Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-076)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-076
Lokale Artikelnummer::
PRSI91-076
Beschreibung:
Annexin A1 is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity. Annexin A1 also has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis, and tumorigenesis and cancer development. ANXA1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-028)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-028
Lokale Artikelnummer::
PRSI91-028
Beschreibung:
Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5013P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5013P
Lokale Artikelnummer::
PRSI5013P
Beschreibung:
TTBK1 peptide is used for blocking the activity of TTBK1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3601P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3601P
Lokale Artikelnummer::
PRSI3601P
Beschreibung:
TRAF3 peptide is used for blocking the activity of TRAF3 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-544)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-544
Lokale Artikelnummer::
PRSI91-544
Beschreibung:
Nectin-3 is a type I transmembrane glycoprotein that belongs to the nectin family. Its precursor is 549 amino acids in length and contains an extended signal sequence of 57 amino acids, an extracellular domain (ECD) of 347 amino acids, a transmembrane segment of 21 amino acids, and a cytoplasmic region of 124 amino acids. It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. Nectin-3 is also involved in the formation of cell-cell junctions, including adherens junctions and synapses.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-070)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-070
Lokale Artikelnummer::
PRSI91-070
Beschreibung:
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
VE:
1 * 50 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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