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Proteine und Peptide
Artikel-Nr:
(PRSI96-478)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-478
Lokale Artikelnummer::
PRSI96-478
Beschreibung:
Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI96-599)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-599
Lokale Artikelnummer::
PRSI96-599
Beschreibung:
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
VE:
1 * 25 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interleukin 8 (IL-8 oder CXCL8) ist ein Mitglied der CXC-Zytokinfamilie und wird von Makrophagen, Epithelzellen, glatten Muskelzellen und Endothelzellen produziert. IL-8 bindet die G-Protein-gekoppelten Serpentinrezeptoren CXCR1 und CXCR2. IL-8 rekrutiert angeborene Immunzellen, induziert die Phagozytose und stimuliert die Angiogenese.
Artikel-Nr:
(PRSI4459P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4459P
Lokale Artikelnummer::
PRSI4459P
Beschreibung:
Slitrk2 peptide is used for blocking the activity of Slitrk2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5249P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5249P
Lokale Artikelnummer::
PRSI5249P
Beschreibung:
Swine H1N1 Neuraminidase peptide is meant to be used as a positive control in ELISA applications to detect Swine-Origin Influenza A antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7221P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7221P
Lokale Artikelnummer::
PRSI7221P
Beschreibung:
16 amino acids near the amino terminus of human TSC22D3.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-013)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-013
Lokale Artikelnummer::
PRSI90-013
Beschreibung:
CD137 (4-1BB) is a member of the tumour necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumours in mice.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6795P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6795P
Lokale Artikelnummer::
PRSI6795P
Beschreibung:
VKORC1 peptide is used for blocking the activity of VKORC1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-413)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-413
Lokale Artikelnummer::
PRSI92-413
Beschreibung:
Mouse SDC4 is a ubiquitous transmembrane proteoglycan which belongs to the syndecan proteoglycan family. SDC4 is a cell surface proteoglycan that bears heparan sulphate. The four vertebrate syndecans, Syndecan-1 through -4, have similar short cytoplasmic domains and extracellular portions that diverge, except for HS attachment sites. Structurally diverse side chains add considerably to the size of the core proteins and serve as binding sites for growth factors, cytokines, and extracellular matrix proteins. Syndecans are present as homodimers or multimers, and are often expressed in developmental and cell type-specific patterns. It is expressed highly in liver, kidney and lung. SDC4 localises to the focal adhesions of adherent cells and binds to a range of extracellular ligands, including growth factors and extracellular-matrix proteins. Through its extracellular domain, syndecan-4 cooperates with adhesion molecules and binds matrix components relevant for cell migration. As a heparan sulphate proteoglycan, SDC4 works as a coreceptor for various growth factors. Syn4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilisation. SDC4 have an array of functions including regulating cell growth, differentiation, and adhesion.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-064)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-064
Lokale Artikelnummer::
PRSI90-064
Beschreibung:
ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI92-166)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-166
Lokale Artikelnummer::
PRSI92-166
Beschreibung:
Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 has been shown to interact with EP300, CREB-binding protein, NFKB1, Nuclear receptor coactivator 1, IRF4 and SND1.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5679P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5679P
Lokale Artikelnummer::
PRSI5679P
Beschreibung:
ZC3H12D peptide is used for blocking the activity of ZC3H12D antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-709)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-709
Lokale Artikelnummer::
PRSI92-709
Beschreibung:
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12R beta 1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophthalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumour.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI1151P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
1151P
Lokale Artikelnummer::
PRSI1151P
Beschreibung:
ASK1 peptide is used for blocking the activity of ASK1 antibody.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
Artikel-Nr:
(PRSI92-641)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-641
Lokale Artikelnummer::
PRSI92-641
Beschreibung:
Endothelial cell-specific molecule–1 (ESM-1)—so-called endocan—is a novel endothelium derived soluble dermatan sulphate proteoglycan (PG) that is constitutively expressed by endothelial cells in lungs and kidneys and can be detected in human blood. It is encoded by the ESM1 gene. The expression of this gene is regulated by several cytokines and growth factors, such as vascular endothelial growth factor. Inflammatory cytokines, such as interleukin (IL)-1 beta and tumour necrosis factor (TNF)- alpha, stimulate the upregulation of endocan mRNA and the secretion of endocan from endothelial cells. The binding of circulating endocan to leukocyte ligand for ICAM-1—Lymphocyte Function-associated Antigen-1 (LFA-1) and to leukocyte ligand for VCAM-1—Very Late Antigen-4 (VLA-4) is important in leukocyte adhesion and interaction with activated endothelium. Endocan is a key player in the regulation of major processes such as cell adhesion in inflammatory disorders and tumour progression.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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