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7-Fluorobenzo[b]thiophene-3-carboxylic+acid
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7-Fluorobenzo[b]thiophene-3-carboxylic+acid
Artikel-Nr:
(BOSSBS-1136R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1136R-A647
Lokale Artikelnummer::
BOSSBS-1136R-A647
Beschreibung:
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).[supplied by OMIM]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11358R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11358R-CY3
Lokale Artikelnummer::
BOSSBS-11358R-CY3
Beschreibung:
RIMS-binding proteins (RIM-BPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. Specifically, RIM-BP2 (RIMS binding protein 2), also known as RBP2, is a 1,052 amino acid protein that links L-type Ca++ CP Alpha1D, N-type Ca++ CP Alpha1B, Rim1 and Rim2 during synaptic transmission. RIM-BP2 contains three fibronectin type-III domains and three SH3 domains, which are used to mediate binding to a proline-rich motifs. Existing as three alternatively spliced isoforms, RIM-BP2 is encoded by a gene that maps to human chromosome 12q24.33 and mouse chromosome 5 G1.3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11358R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11358R-CY7
Lokale Artikelnummer::
BOSSBS-11358R-CY7
Beschreibung:
RIMS-binding proteins (RIM-BPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. Specifically, RIM-BP2 (RIMS binding protein 2), also known as RBP2, is a 1,052 amino acid protein that links L-type Ca++ CP Alpha1D, N-type Ca++ CP Alpha1B, Rim1 and Rim2 during synaptic transmission. RIM-BP2 contains three fibronectin type-III domains and three SH3 domains, which are used to mediate binding to a proline-rich motifs. Existing as three alternatively spliced isoforms, RIM-BP2 is encoded by a gene that maps to human chromosome 12q24.33 and mouse chromosome 5 G1.3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6425R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6425R-FITC
Lokale Artikelnummer::
BOSSBS-6425R-FITC
Beschreibung:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11358R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11358R-A350
Lokale Artikelnummer::
BOSSBS-11358R-A350
Beschreibung:
RIMS-binding proteins (RIM-BPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. Specifically, RIM-BP2 (RIMS binding protein 2), also known as RBP2, is a 1,052 amino acid protein that links L-type Ca++ CP Alpha1D, N-type Ca++ CP Alpha1B, Rim1 and Rim2 during synaptic transmission. RIM-BP2 contains three fibronectin type-III domains and three SH3 domains, which are used to mediate binding to a proline-rich motifs. Existing as three alternatively spliced isoforms, RIM-BP2 is encoded by a gene that maps to human chromosome 12q24.33 and mouse chromosome 5 G1.3.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 1784-03-8
Lieferant:
VWR Chemicals
Beschreibung:
CaCO₃ gelöst in HNO₃ 2 - 5%.
Artikel-Nr:
(BOSSBS-8592R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8592R-CY3
Lokale Artikelnummer::
BOSSBS-8592R-CY3
Beschreibung:
Rad and Gem related GTP binding protein (REM) is a member of the RGK subfamily of Ras-like GTPases that also includes Rad, REM2 and Gem/Kir. REM is a phosphorylated protein that is highly expressed in cardiac muscle and moderately expressed in lung, kidney and skeletal muscle. REM associates with several 14-3-3 isoforms as well as with calmodulin in a calcium-dependent manner. REM mediates two distinct signal transduction pathways that regulate both cytoskeletal reorganization and voltage-gated calcium channel activity. REM decreases the current that passes through cardiac voltage-gated L-type Ca channels (Ca(V)). Overexpression of REM may result in the development of cytoplasmic processes, reorganization of the Actin cytoskeleton, reduction in focal adhesion size and an elongated or dendritic-like cell morphology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4682R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4682R-A680
Lokale Artikelnummer::
BOSSBS-4682R-A680
Beschreibung:
Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilisation and interferon-gamma production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11983R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11983R-A488
Lokale Artikelnummer::
BOSSBS-11983R-A488
Beschreibung:
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta 4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta 4, also known as CACNB4 (Calcium channel voltage-dependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 4 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta4 exist due to alternative splicing events.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 176763-62-5
Artikel-Nr:
(BOSSBS-9871R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9871R-A750
Lokale Artikelnummer::
BOSSBS-9871R-A750
Beschreibung:
Sorcin is a highly conserved protein, with 95% homology between hamster and human sorcin sequences. Sorcin has four putative Ca-binding domains, two of which exhibit strong homology to calmodulin EF hand motifs. Calcium binding directly to sorcin has been demonstrated by in vitro assays. Sorcin is closely related to members of calpain and sarcoplasmic Ca²⁺ binding protein subfamilies. Sorcin undergoes calcium-dependent translocation from the cytosol to cellular membranes. Sorcin binds to and modulates ryanodine receptors and is widely distributed including heart and brain tissues. At the subcellular level, sorcin localizes to T-tubule junctions of cardiac sarcoplasmic reticulum.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3666R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3666R-CY5
Lokale Artikelnummer::
BOSSBS-3666R-CY5
Beschreibung:
Calmodulin consists of two glycoproteins, 34 and 39 kDa, sometimes designated epithelial antigen, epithelial specific antigen, and epithelial glycoprotein. The glycoproteins are located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells with the exception of most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. Epithelial Calmodulin is found in the large majority of adenocarcinomas of most sites (50-100% in various studies; as well as neuroendocrine tumours, including small cell carcinoma. Renal cell carcinoma and hepatocellular carcinoma stain in about 30% of the cases. Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin Ca(2+) complex are a number of protein kinases and phosphatases. Calmodulin has four functional calcium binding sites.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4682R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4682R-HRP
Lokale Artikelnummer::
BOSSBS-4682R-HRP
Beschreibung:
Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6425R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6425R-A350
Lokale Artikelnummer::
BOSSBS-6425R-A350
Beschreibung:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6425R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6425R-A680
Lokale Artikelnummer::
BOSSBS-6425R-A680
Beschreibung:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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