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4-Chloro-1H-pyrazolo[4,3-c]pyridine
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4-Chloro-1H-pyrazolo[4,3-c]pyridine
Artikel-Nr:
(BOSSBS-13664R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13664R-CY7
Lokale Artikelnummer::
BOSSBS-13664R-CY7
Beschreibung:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13664R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13664R-A750
Lokale Artikelnummer::
BOSSBS-13664R-A750
Beschreibung:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
VE:
1 * 100 µl
Artikel-Nr:
(APOSPC408299-500MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC408299-500MG
Lokale Artikelnummer::
APOSPC408299-500MG
Beschreibung:
3'-Chloro-5'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-ylamine hydrochloride
VE:
1 * 500 mg
Lieferant:
Alfa Aesar
Beschreibung:
Crocein scarlet 7B ≥70% (Farbstoffgehalt)
Artikel-Nr:
(APOSPC410108-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC410108-1G
Lokale Artikelnummer::
APOSPC410108-1G
Beschreibung:
2-[4-Amino-3-(trifluoromethyl)-1H-pyrazol-1-yl]butanoic acid hydrochloride
VE:
1 * 1 g
Artikel-Nr:
(APOSOR475057-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR475057-1G
Lokale Artikelnummer::
APOSOR475057-1G
Beschreibung:
Ethyl 2-[[[(1S)-1-(4-bromophenyl)ethyl]amino]methyl]benzoate hydrochloride
VE:
1 * 1 g
Artikel-Nr:
(BLDPBD33651-100G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD33651-100G
Lokale Artikelnummer::
BLDPBD33651-100G
Beschreibung:
Ethyl-1-aminocyclopropancarboxylathydrochlorid 95%
VE:
1 * 100 g
Artikel-Nr:
(BLDPBD159110-250MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD159110-250MG
Lokale Artikelnummer::
BLDPBD159110-250MG
Beschreibung:
5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride 95%
VE:
1 * 250 mg
Artikel-Nr:
(BOSSBS-13664R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13664R-A488
Lokale Artikelnummer::
BOSSBS-13664R-A488
Beschreibung:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13664R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13664R-A555
Lokale Artikelnummer::
BOSSBS-13664R-A555
Beschreibung:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
Appearance: White to off-white Powder
Lieferant:
Restek
Beschreibung:
The biodiesel component is methyl soyate.
Lieferant:
Thermo Scientific
Beschreibung:
Ethyl-1-aminocyclopropancarboxylathydrochlorid 98%
Lieferant:
Biotium
Beschreibung:
This MAb recognizes a protein of 134 kDa, which binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). Fucosylation is essential for binding to E-selectin. It contains sialic acid residues and 16 Cys-rich GLG1 repeats. This MAb can be used to stain the Golgi complex in cell or tissue preparations and can be used as a Golgi marker in subcellular fractions. It produces a diffuse staining pattern of the Golgi zone in normal and malignant cells. This MAb is an excellent marker for human cells in xenographic model research. It reacts specifically with human cells. The Golgi apparatus is an organelle present in all eukaryotic cells that forms a part of the endomembrane system. The primary function of the Golgi apparatus is to process and package macromolecules synthesized by the cell for exocytosis or use within the cell. The Golgi is made up of a stack of flattened, membrane-bound sacs known as cisternae, with three functional regions: the cis face, medial region and trans face. Each region consists of various enzymes that selectively modify the macromolecules passing though them, depending on where they are destined to reside. Several spherical vesicles that have budded off of the Golgi are present surrounding the main cisternae. The Golgi tends to be more pronounced and numerous in cells that make and secrete many substances such as plasma B cells.
Artikel-Nr:
(BLDPBD5148-5G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD5148-5G
Lokale Artikelnummer::
BLDPBD5148-5G
Beschreibung:
1-(3-Chlor-4-methoxyphenyl)methanaminhydrochlorid 98%
VE:
1 * 5 g
Artikel-Nr:
(FLUO011793-50G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
011793-50G
Lokale Artikelnummer::
FLUO011793-50G
Beschreibung:
Maleimid
VE:
1 * 50 g
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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