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4,4-Dimethoxybutanon
Artikel-Nr:
(BOSSBS-0483R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0483R-A488
Lokale Artikelnummer::
BOSSBS-0483R-A488
Beschreibung:
Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely via acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1Alpha/Beta. The enzymes responsible for H3K9me3 formation are SUV39H1 and SUV39H2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0483R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0483R-A350
Lokale Artikelnummer::
BOSSBS-0483R-A350
Beschreibung:
Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely via acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1Alpha/Beta. The enzymes responsible for H3K9me3 formation are SUV39H1 and SUV39H2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3477R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3477R-HRP
Lokale Artikelnummer::
BOSSBS-3477R-HRP
Beschreibung:
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0615R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0615R-CY5
Lokale Artikelnummer::
BOSSBS-0615R-CY5
Beschreibung:
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0615R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0615R-CY3
Lokale Artikelnummer::
BOSSBS-0615R-CY3
Beschreibung:
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9446R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9446R-A555
Lokale Artikelnummer::
BOSSBS-9446R-A555
Beschreibung:
AMPK is a heterotrimeric complex comprising a catalytic a subunit and regulatory b and g subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKa1 and AMPKa2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKb1 encodes a 271 amino acid protein and human AMPKb2 encodes a 272 amino acid protein. The human AMPKg1 gene encodes a 331 amino acid protein. Human AMPKg2 and AMPKg3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.
VE:
1 * 100 µl
Lieferant:
Merck
Beschreibung:
Tetrabutylammoniumchlorid zur Synthese, Sigma-Aldrich®
Artikel-Nr:
(APOSOR346585-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR346585-1G
Lokale Artikelnummer::
APOSOR346585-1G
Beschreibung:
4,6-Dichloro-pyrimidine-5-carbonyl chloride 95+%
VE:
1 * 1 g
Artikel-Nr:
(USBI041726)
Lieferant:
US Biological
Hersteller-Artikelnummer::
041726
Lokale Artikelnummer::
USBI041726
Beschreibung:
Anti-SIA8C Rabbit Polyclonal Antibody
VE:
1 * 200 µl
Lieferant:
Merck
Beschreibung:
(2-Chlorethyl)diisopropylammoniumchlorid, Sigma-Aldrich®
Lieferant:
Alfa Aesar
Beschreibung:
Methyltributylammoniumchlorid ≥75% Aliquat 175
Lieferant:
Cayman Chemical
Beschreibung:
Diphenyleniodoniumchlorid
Artikel-Nr:
(87765.290)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC87765.290
Beschreibung:
Starting materials: Aluminium chloride R / Glacial acetic acid R/ Methanol R.
VE:
1 * 1 L
Lieferant:
Alfa Aesar
Beschreibung:
(4-Nitrophenyl)methansulfonsäurechlorid ≥97%
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 25702-80-1
Artikel-Nr:
(ACRO115835000)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
115835000
Lokale Artikelnummer::
ACRO115835000
Beschreibung:
(2-Chlorpropyl)dimethylammoniumchlorid 98.5%
VE:
1 * 500 g
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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