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4-Chlor-1,8-naphthalsäureanhydrid
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Ethyl-4,4,4-trifluoro-3-(trifluoromethyl)crotonate 95%
Artikel-Nr:
(BOSSBS-15482R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-CY3
Lokale Artikelnummer::
BOSSBS-15482R-CY3
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15482R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-HRP
Lokale Artikelnummer::
BOSSBS-15482R-HRP
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15482R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-A350
Lokale Artikelnummer::
BOSSBS-15482R-A350
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Ethyl-3,4-dihydro-2H-1,4-benzoxazine 98%
Artikel-Nr:
(H33837.03)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
H33837.03
Lokale Artikelnummer::
ALFAH33837.03
Beschreibung:
Ethyl-2-amino-4,4,4-trifluoro-3-(trifluoromethyl)butyrate 95%
VE:
1 * 1 g
Artikel-Nr:
(BLDPBD00935290-250)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD00935290-250
Lokale Artikelnummer::
BLDPBD00935290-250
Beschreibung:
Ethyl(imino)(methyl)-l6-sulphanone 95%
VE:
1 * 250 mg
Lieferant:
Merck
Beschreibung:
Propiophenon zur Synthese, Sigma-Aldrich®
Artikel-Nr:
(APOSPC210004-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC210004-1G
Lokale Artikelnummer::
APOSPC210004-1G
Beschreibung:
N-(2-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)-4-nitrobenzamide
VE:
1 * 1 g
Artikel-Nr:
(APOSOR53171-100G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR53171-100G
Lokale Artikelnummer::
APOSOR53171-100G
Beschreibung:
Ethyl acetoacetate propylene glycol ketal 98+%
VE:
1 * 100 g
Artikel-Nr:
(BLDPBD628200-250MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD628200-250MG
Lokale Artikelnummer::
BLDPBD628200-250MG
Beschreibung:
2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl acrylate 97% + stabilisiert
VE:
1 * 250 mg
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-[2-(tert-Butyldimethylsiloxy)ethyl]benzeneboronic acid 96%
Artikel-Nr:
(BLDPBD306898-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD306898-1G
Lokale Artikelnummer::
BLDPBD306898-1G
Beschreibung:
1-tert-Butyl-4-ethyl-4-(4-fluorobenzyl)piperidine-1,4-dicarboxylate 98%
VE:
1 * 1 g
Artikel-Nr:
(APOSPC200462-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC200462-1G
Lokale Artikelnummer::
APOSPC200462-1G
Beschreibung:
N-(2-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)acetamide
VE:
1 * 1 g
Artikel-Nr:
(09206-1ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
09206-1ML
Lokale Artikelnummer::
SUPL09206-1ML
Beschreibung:
Organic Standard, (+/-)-alpha-Terpinyl acetate, predominantly alpha-isomer, ≤15% (γ-isomer, GC), ≥85% (α-isomer, GC), ≥97,0% (sum of isomers, GC)
VE:
1 * 1 mL
Artikel-Nr:
(APOSPC52170-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC52170-1G
Lokale Artikelnummer::
APOSPC52170-1G
Beschreibung:
Ethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2,2-difluoroacetate
VE:
1 * 1 g
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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