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Allyl+1H,1H-heptafluorobutyl+ether
Artikel-Nr:
(PRSI90-519)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-519
Lokale Artikelnummer::
PRSI90-519
Beschreibung:
Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.
VE:
1 * 25 µG
Artikel-Nr:
(PRSI91-493)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-493
Lokale Artikelnummer::
PRSI91-493
Beschreibung:
Serine Protease Inhibitor Kazal-Type 4 (SPINK4) is a secreted protein containing one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6781P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6781P
Lokale Artikelnummer::
PRSI6781P
Beschreibung:
TMEM106A peptide is used for blocking the activity of TMEM106A antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-913)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-913
Lokale Artikelnummer::
PRSI91-913
Beschreibung:
CD83 antigen is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. It contains one Ig-like V-type (immunoglobulin-like) domain. , the soluble CD83 has the opposite effect and has an immune inhibitory capacity. Due to its immune inhibitory function, CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI2481)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2481
Lokale Artikelnummer::
PRSI2481
Beschreibung:
TCCR Antibody: Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI96-569)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-569
Lokale Artikelnummer::
PRSI96-569
Beschreibung:
Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI90-123)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-123
Lokale Artikelnummer::
PRSI90-123
Beschreibung:
DLL1 (Delta-like protein; Delta1) is essential for postnatal arteriogenesis and contributes to tumour progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI90-392)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-392
Lokale Artikelnummer::
PRSI90-392
Beschreibung:
CD28 and CTLA-4 together with their ligands, CD80 (B7-1) and CD86 (B7-2), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD28 and CTLA-4 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD28 and CTLA-4 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2 and mouse chromosome 1. Mouse CD28 is expressed constitutively on virtually 100% of mouse T cells and on developing thymocytes. Cell surface expression of mouse CD28 is downregulated upon ligation of CD28 in the presence of PMA or PHA. In contrast, CTLA-4 is not expressed constitutively but is upregulated rapidly following T cell activation and CD28 ligation. Cell surface expression of mouse CTLA-4 peaks approx.y 48 hours after activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28. CD28/B7 interaction has been shown to prevent apoptosis of activated T cells via the upregulation of bcl-XL. CD28 ligation has also been shown to regulate Th1/Th2 differentiation.
VE:
1 * 200 µG
Artikel-Nr:
(PRSI96-647)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-647
Lokale Artikelnummer::
PRSI96-647
Beschreibung:
Renin is also known as REN and angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), and plays an essential role in the elevation of arterial blood pressure and increased sodium retention by the kidney. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. Renin is secreted from kidney cells, which are activated via signaling from the macula densa, which responds to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by sympathetic nervous stimulation, mainly through beta-1 receptor activation. Renin can bind to ATP6AP2, which results in a fourfold increase in the conversion of angiotensinogen to angiotensin I over that shown by soluble renin. In addition, renin binding results in phosphorylation of serine and tyrosine residues of ATP6AP2. The level of renin mRNA appears to be modulated by the binding of HADHB, HuR and CP1 to a regulatory region in the 3' UTR. An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. These effects lead to hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI7221P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7221P
Lokale Artikelnummer::
PRSI7221P
Beschreibung:
16 amino acids near the amino terminus of human TSC22D3.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-447)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-447
Lokale Artikelnummer::
PRSI90-447
Beschreibung:
Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signallling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5249P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5249P
Lokale Artikelnummer::
PRSI5249P
Beschreibung:
Swine H1N1 Neuraminidase peptide is meant to be used as a positive control in ELISA applications to detect Swine-Origin Influenza A antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3201)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3201
Lokale Artikelnummer::
PRSI3201
Beschreibung:
ILPIP Antibody: ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 beta converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI25-382)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-382
Lokale Artikelnummer::
PRSI25-382
Beschreibung:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNV1 is a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types.Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI2265)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2265
Lokale Artikelnummer::
PRSI2265
Beschreibung:
Nephrin Antibody: Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI28-391)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-391
Lokale Artikelnummer::
PRSI28-391
Beschreibung:
ZNF358, a gene located on chromosome 19, encodes a protein involved in embryogenesis.
VE:
1 * 100 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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