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5-(3-Chlorophenyl)-3-hydroxypicolinic+acid
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5-(3-Chlorophenyl)-3-hydroxypicolinic+acid
Artikel-Nr:
(PRSI96-539)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-539
Lokale Artikelnummer::
PRSI96-539
Beschreibung:
Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4749)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4749
Lokale Artikelnummer::
PRSI4749
Beschreibung:
Adenovirus-9 E4 Orf1 Antibody: The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4). The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI50-263)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
50-263
Lokale Artikelnummer::
PRSI50-263
Beschreibung:
Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI4037)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4037
Lokale Artikelnummer::
PRSI4037
Beschreibung:
MDA5 Antibody: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kappa B. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4039)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4039
Lokale Artikelnummer::
PRSI4039
Beschreibung:
MDA5 Antibody: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kappa B. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.
VE:
1 * 100 µG
Lieferant:
MP Biomedicals
Beschreibung:
Piperacillin is a semisynthetic, broad-spectrum ureidopenicillin antibiotic. It is derived from ampicillin. Piperacillin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Piperacillin may interfere with autolysin inhibitors.
It has been used in pharmacokinetic studies in order to optimize antimicrobial therapy in patients with sepsis. It is used to study piperacillin hypersensitivity reactions and to study multidrug-resistant organisms. Piperacillin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Piperacillin may interfere with autolysin inhibitors.
Artikel-Nr:
(PRSI34-055)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-055
Lokale Artikelnummer::
PRSI34-055
Beschreibung:
T-Cell Intracellular Antigen-1 is a cytoplasmic granule-associated protein expressed in lymphocytes processing cytolytic potential. It is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognises poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing. TIA-1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(1.07222.1000)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.07222.1000
Lokale Artikelnummer::
MERC1.07222.1000
Beschreibung:
Peracetic acid ∼38 - 40%, Supelco®
VE:
1 * 1 L
Lieferant:
Sigma-Aldrich
Beschreibung:
Nitric acid : Dipicolinic acid (34 mM : 14 mM) in Wasser Eluenskonzentrat für IC (20x) for Metrosep C 4, Supelco®
Artikel-Nr:
(276235-1G)
Lieferant:
SIGMA ALDRICH MICROSCOPY
Hersteller-Artikelnummer::
276235-1G
Lokale Artikelnummer::
SIAM276235-1G
Beschreibung:
Building block for 'Anti-Bredt' strained molecules.
VE:
1 * 1 g
Lieferant:
MP Biomedicals
Beschreibung:
Cefotaxime is a cephalosporin, which acts by interference of synthesis of peptidoglycan of the bacterial cell wall. Cefotaxime, a cephalosporin antibiotic, is active against both gram-negative and gram-positive bacteria. In addition, cefotaxime blocks the division of cyanobacteria and lower plant organelles/plastids such as the photosynthetic organelles of Glaucophytes and chloroplasts of bryophytes.
Cefotaxime is used for infections of the respiratory tract, skin, bones, joints, urogenital system, meninges, and bloodstream. It generally has good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas. It is also effective against most Gram-positive cocci except for Enterococcus. It is active against penicillin-resistant strains of Streptococcus pneumoniae. It has modest activity against the anaerobic Bacteroides fragilis. In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime. Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Lieferant:
Merck
Beschreibung:
D-Glucoronic acid zur Synthese, Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
Nitric acid : Dipicolinic acid (Konzentrat) (17 mM : 17 mM) in Wasser Eluenskonzentrat für IC (10x) for Metrosep C 6, Supelco®
Artikel-Nr:
(309052-25G)
Lieferant:
SIGMA ALDRICH MICROSCOPY
Hersteller-Artikelnummer::
309052-25G
Lokale Artikelnummer::
SIAM309052-25G
Beschreibung:
Quinoline Yellow, Mixture of the mono- and disulfonic acids of Quinoline Yellow (Acid Yellow 3)
VE:
1 * 25 g
Artikel-Nr:
(1.07916.1000)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.07916.1000
Lokale Artikelnummer::
MERC1.07916.1000
Beschreibung:
PSS (phosphoric acid, sulphuric acid), Spectrosolv® Säureleerprobe, für den ACIDORAPID® Mineralisator, Supelco®
VE:
1 * 1 L
Artikel-Nr:
(1.01306.0025)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.01306.0025
Lokale Artikelnummer::
MERC1.01306.0025
Beschreibung:
Acid green 1 Indikator (C.I. 10020), Millipore®
VE:
1 * 25 g
Preis auf Anfrage
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noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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