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17-Octadecinsäure
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17-Octadecinsäure
Artikel-Nr:
(BOSSBS-11296R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11296R-CY5
Lokale Artikelnummer::
BOSSBS-11296R-CY5
Beschreibung:
17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
VE:
1 * 100 µl
Lieferant:
Bernd Kraft
Beschreibung:
Ammoniaklösung 17% analytisches Reagens
Artikel-Nr:
(USBI033311)
Lieferant:
US Biological
Hersteller-Artikelnummer::
033311
Lokale Artikelnummer::
USBI033311
Beschreibung:
Anti-CCDC17 Rabbit Polyclonal Antibody
VE:
1 * 200 µl
Artikel-Nr:
(PRSI4059P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4059P
Lokale Artikelnummer::
PRSI4059P
Beschreibung:
The peptide is used for blocking the activity of PDL-1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(ABNOPAB8213)
Lieferant:
Abnova
Hersteller-Artikelnummer::
PAB8213
Lokale Artikelnummer::
ABNOPAB8213
Beschreibung:
Sheep polyclonal antibody raised against 17 beta-Testosterone-long linker.
VE:
1 * 1 mg
Artikel-Nr:
(ABNOPAB8201)
Lieferant:
Abnova
Hersteller-Artikelnummer::
PAB8201
Lokale Artikelnummer::
ABNOPAB8201
Beschreibung:
Sheep polyclonal antibody raised against 17 alpha-OH-Progesterone.
VE:
1 * 1 mg
Artikel-Nr:
(ABNOPAB8198)
Lieferant:
Abnova
Hersteller-Artikelnummer::
PAB8198
Lokale Artikelnummer::
ABNOPAB8198
Beschreibung:
Sheep polyclonal antibody raised against 17 alpha-19-Nortestosterone.
VE:
1 * 1 mg
Artikel-Nr:
(BOSSBS-4197R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4197R-A555
Lokale Artikelnummer::
BOSSBS-4197R-A555
Beschreibung:
The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser-10, Ser-16, Thr-17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4197R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4197R-A750
Lokale Artikelnummer::
BOSSBS-4197R-A750
Beschreibung:
The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser-10, Ser-16, Thr-17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Recognizes a phosphorylated protein of 228 kDa, identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis, it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase, the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200 kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.
Artikel-Nr:
(BOSSBS-9366R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9366R-A488
Lokale Artikelnummer::
BOSSBS-9366R-A488
Beschreibung:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7689R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7689R-A680
Lokale Artikelnummer::
BOSSBS-7689R-A680
Beschreibung:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13606R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13606R-A750
Lokale Artikelnummer::
BOSSBS-13606R-A750
Beschreibung:
Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NF_B expression, thereby inhibiting NF_B-mediated cellular functions. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 480 amino acid nuclear protein that contains one BTB (POZ) domain and five C2H2-type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development. The gene encoding Bcl-6b maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0644R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0644R-A680
Lokale Artikelnummer::
BOSSBS-0644R-A680
Beschreibung:
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI2327P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2327P
Lokale Artikelnummer::
PRSI2327P
Beschreibung:
Caspase-12 peptide is used for blocking the activity of caspase-12 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-3451R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3451R-A680
Lokale Artikelnummer::
BOSSBS-3451R-A680
Beschreibung:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyses the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localised to chromsome 17 and the beta gene is localised to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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