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17-Octadecinsäure
Lieferant:
MP Biomedicals
Beschreibung:
Cholic acid is a biochemical solubilizing agent (a non-ionic, non-denaturing detergent). Occurs inconjugation with glycine or taurine in bile of most vertebrates.
Artikel-Nr:
(PRSI90-525)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-525
Lokale Artikelnummer::
PRSI90-525
Beschreibung:
Interleukin-23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 Rbeta1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naie and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8-and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumour/self peptide.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI29-269)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-269
Lokale Artikelnummer::
PRSI29-269
Beschreibung:
CSH1 is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
VE:
1 * 100 µG
Artikel-Nr:
(UPTIUP15426D)
Lieferant:
Uptima
Hersteller-Artikelnummer::
UP15426D
Lokale Artikelnummer::
UPTIUP15426D
Beschreibung:
3,3',5,5'-Tetramethylbenzidin (TMB), Pulver, ultrarein
VE:
1 * 1 g
Artikel-Nr:
(PRSI79-621)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-621
Lokale Artikelnummer::
PRSI79-621
Beschreibung:
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-κ-B. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI33-473)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-473
Lokale Artikelnummer::
PRSI33-473
Beschreibung:
This antibody neutralises human TNFa mediated cytotoxicity of L929 cells and inhibits tumour growth in mice. It protects mice against toxicity of hTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.
VE:
1 * 100 µG
Lieferant:
LAUDA
Beschreibung:
Die kompakten Variocool Umlaufkühler eignen sich ideal für anspruchsvolle Temperieraufgaben in Labors, Mini-Anlagen und der Produktion. Die Geräte sind mit TFT-Farbbildschirm und Folientastatur, USB-Schnittstelle und integriertem Alarm ausgestattet, die sich leicht zugänglich an der Vorderseite des Geräts befinden. Sie verfügen zudem über eine elektronische Füllstandsanzeige auf dem Display und einen Alarm bei zu niedrigem Füllstand. Die Modelle können entweder luft- oder wassergekühlt sein, und alle haben feststellbare Rollen. Es steht eine große Auswahl an werkseitig eingepassten Optionen und Schnittstellen zur Verfügung, die nachgerüstet werden können und dem Benutzer eine größere Flexibilität und Kontrolle bieten. Optionen umfassen Hochleistungspumpen für einen höheren Eingangsdruck, an die Kühlleistung angepasste Heizelemente für ein schnelles Aufheizen, Durchflussregelung, Installation im Freien, Verwendung mit entionisiertem Wasser und Geräuschdämpfung. Optionale verfügbare Schnittstellen umfassen Analogmodul, RS232/485, Kontaktmodule, Profibus und PT100/LiBus-Module, um eine individuelle Anpassung des Geräts an die Anwendungen zu erleichtern. Für weitere Informationen zu den Optionen und Schnittstellen wenden Sie sich bitte an Ihr Avantor-Vertriebszentrum.
Artikel-Nr:
(REST31222)
Lieferant:
Restek
Hersteller-Artikelnummer::
31222
Lokale Artikelnummer::
REST31222
Beschreibung:
D2887 calibration mix contains compound, conc.; (C6) n-hexane (110-54-3), 6% w/w; (C7) n-heptane (142-82-5), 6% w/w; (C8) n-octane (111-65-9), 8% w/w; (C9) n-nonane (111-84-2), 8% w/w; (C10) n-decane (124-18-5), 12% w/w; (C11) n-undecane (1120-21-4), 12% w/w; (C12) n-dodecane (112-40-3), 12% w/w; (C14) n-tetradecane (629-59-4), 12% w/w; (C16) n-hexadecane (544-76-3), 10% w/w; (C18) n-octadecane (593-45-3), 5% w/w; (C20) n-eicosane (112-95-8), 2% w/w; (c24) n-tetracosane (646-31-1), 2% w/w; (c28) n-octacosane (630-02-4), 1% w/w; (C32) n-dotriacontane (544-85-4), 1% w/w; (C36) n-hexatriacontane (630-06-8), 1% w/w; (C40) n-tetracontane (4181-95-7), 1% w/w; (C44) n-tetratetracontane (7098-22-8), 1% w/w.
VE:
1 * 1 ST
Lieferant:
MP Biomedicals
Beschreibung:
3,3',5,5'-Tetramethylbenzidine is suitable as peroxidase substrate for use in ELISA procedures. The substrate produces a soluble end product that is pale blue in color and can be read spectrophotometrically at 370 or 620 to 650 nm. The TMB reaction may be stopped with 2 M H<sub>2</sub>SO<sub>4</sub> (resulting in a yellow color), and read at 450 nm. A sensitive and specific reagent for the detection of blood, assay of hemoglobin, assay of peroxidases. It is useful in gel staining procedure for low levels of home-associated peroxidases and for enzyme immunoassay of horseradish peroxidase.
Artikel-Nr:
(PRSI34-145)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-145
Lokale Artikelnummer::
PRSI34-145
Beschreibung:
Cytokeratin 17 (CK17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IF's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. CK17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered an epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. CK17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20% of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-522)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-522
Lokale Artikelnummer::
PRSI92-522
Beschreibung:
Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signalling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesised in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signalling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-587)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-587
Lokale Artikelnummer::
PRSI91-587
Beschreibung:
Mouse Interleukin-36 alpha(Il-36a)is a member of the IL-1 family.IL¬1 alpha,IL¬1 beta and IL-18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Il36a is expressed in many cells, including monocytes, B cells, and T cells, immune system and fetal brains. Il36a is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Moreover, it is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and can induce the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.
VE:
1 * 50 µG
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 53-43-0
Artikel-Nr:
(BSENR-1694-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-1694-100
Lokale Artikelnummer::
BSENR-1694-100
Beschreibung:
The spectrin family of proteins were originally discovered as major components of the submembraneous cytoskeleton of osmotically lysed red blood cells (1). The lysed blood cells could be seen as clear red blood cell shaped objects in the light microscope and were referred to as red cell "ghosts". The major proteins of these ghosts proved to be actin, ankyrin, band 4.1 and several other proteins, including two major bands running at about 240kDa and 260kDa on SDS-PAGE gels. This pair of bands was named "spectrin" since they were discovered in these red blood cell ghosts (1). Later work showed that similar high molecular bands were seen in membrane preparations from other eukaryotic cell types. Work by Levine and Willard described a pair of about ~240-260kDa molecular weight bands which were transported at the slowest rate along mammalian axons (2). They named these proteins "fodrin" as antibody studies showed that they were localized in the sheath under the axonal membrane, but not in the core of the axon (2; fodros is Greek for sheath). Subsequently fodrin was found to be a member of the spectrin family of proteins, and the spectrin nomenclature is now normally used (3). Spectrins form tetramers of two alpha and two beta subunits, with the alpha corresponding to the lower molecular weight ~240kDa band and the beta corresponding to the ~260kDa or in some case much larger band. Most spectrin tetramers are about 0.2microns or 200nm long, and each alpha and beta subunit has a cell type specific expression pattern. The basic structure of each spectrin subunit is the spectrin repeat, which is a sequence of about 110 amino acids which defines a compact domain contain three closely packed alpha-helices. Each spectrin subunit contains multiple copies of this repeat, with 20 in each of the alpha subunits. The beta I-IV subunits each contain 17 spectrin repeats, while the beta V subunit, also known as beta-heavy spectrin, contains 30 of these repeats. The various subunits also contain several other kinds of functional domain, allowing the spectrin tetramer to interact with a variety of protein, ionic and lipid targets. The alpha-subunits each contain one calmodulin like calcium binding region and one Src-homology 3 (SH3) domain, an abundant domain involved in specific protein-protein interactions. The beta subunits all have a N-terminal actin binding domain and may also have one SH3 domain and one pleckstrin homology domain, a multifunctional type of binding domain which in beta I spectrin at least binds the membrane lipid PIP2 (5). Spectrins are believed to have a function in giving mechanical strength to the plasma membrane since the tetramers associate with each other to form a dense submembraneous geodesic meshwork (3). They also bind a variety of other membrane proteins and membrane lipids, and the proteins they bind to are therefore themselves localized in the membrane. Diseases may be associated with defects in one or other of the spectrin subunits (6). For example, some forms of hereditary spherocytosis, the presence of spherical red blood cells which are prone to lysis, can be traced to mutations in some of the spectrin subunits (7). The alpha-II subunit is widely expressed in tissues but, in the nervous system, is found predominantly in neurons. The antibody can therefore be used to identify neurons and fragments derived from neuronal membranes in cells in tissue culture and in sectioned material.
VE:
1 * 100 µl
Lieferant:
HUBER
Beschreibung:
Dank der kompakten Abmessungen können Ministats auf engstem Raum platziert werden, z. B. in einem Labor-Abzug oder einer technischen Anlage. Trotz ihrer geringen Größe verfügen die Systeme über eine Vielzahl von Funktionen und bieten Leistungsniveaus, die sich für die Temperierung von Photometern, Refraktometern, Viskosimetern, Destillationsgeräten, Reaktionsgefäßen und Modellanlagen eignen. Sie werden hauptsächlich für externe Anwendungen verwendet, über die Badöffnung können Objekte jedoch direkt in einem Thermostatbad temperiert werden. Eine leistungsstarke Druck-/Saugpumpe mit stufenlos regelbarer Drehzahl garantiert eine optimale Zirkulation. Der maximale Druck kann über einen optionalen Drucksensor ebenfalls reguliert werden, was bedeutet, dass empfindliche Glasreaktoren und -geräte vor Bruch geschützt werden können. Die Ministats® sind standardmäßig mit dem „professionellen“ Pilot ONE® Controller mit TFT-Farbdisplay und praktischer Bedienerführung ausgestattet. Analoge NAMUR Verbindungen sind über das optionale Com.G@te Modul möglich, wodurch die Ministats in Anlagen- und Prozessleitsysteme integriert werden können. Der Pilot ONE® Multi-Touch-Controller verfügt über einen brillanten 14,5-cm-Touchscreen mit grafischen Funktionen und einfachem Navigationsmenü in 11 Sprachen. Alle wichtigen Betriebsparameter und Temperaturwerte werden übersichtlich auf dem Touchscreen dargestellt. Das Favoritenmenü, Ein-Klick-Bedienung und das integrierte Technik-Glossar sorgen für eine einfache Bedienung. Integrierte USB- und Ethernet-Anschlüsse ermöglichen die Verbindung mit einem PC oder Netzwerk, z. B. für die Fernbedienung oder Datenübertragung.
Artikel-Nr:
(662-2305)
Lieferant:
Thermo Orion
Hersteller-Artikelnummer::
9512HPBNWP
Lokale Artikelnummer::
ORIO9512HPBNWP
Beschreibung:
The high performance ammonia ion selective electrode (ISE) allows fast, simple, economical, and accurate measurements of dissolved ammonia in aqueous solutions.
VE:
1 * 1 ST
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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