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2-Bromo-4-chloro-5-fluorobenzoic+acid
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2-Bromo-4-chloro-5-fluorobenzoic+acid
Artikel-Nr:
(APOSOR8129-250MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR8129-250MG
Lokale Artikelnummer::
APOSOR8129-250MG
Beschreibung:
Methyl 5-(chlorosulphonyl)-1-methyl-1H-pyrrole-2-carboxylate
VE:
1 * 250 mg
Lieferant:
MACRON AVANTOR BRAND
Beschreibung:
Salzsäure-Lösung 10% Biotech Reagent, erfüllt analytische Spezifikationen von Ph.Eur., Macron Fine Chemicals™
Artikel-Nr:
(BOSSBS-11952R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11952R-CY7
Lokale Artikelnummer::
BOSSBS-11952R-CY7
Beschreibung:
The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3766R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3766R-CY5.5
Lokale Artikelnummer::
BOSSBS-3766R-CY5.5
Beschreibung:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6634R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-HRP
Lokale Artikelnummer::
BOSSBS-6634R-HRP
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(5616-02)
Lieferant:
Avantor
Lokale Artikelnummer::
BAKR5616-02
Beschreibung:
Standardised at 25 °C against chemicals whose certification is traceable to NIST. Lot standardisation value, accurate to ±1 part per 1000, provided on label.
VE:
1 * 1 L
Artikel-Nr:
(BOSSBS-6981R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6981R-CY3
Lokale Artikelnummer::
BOSSBS-6981R-CY3
Beschreibung:
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6981R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6981R-A488
Lokale Artikelnummer::
BOSSBS-6981R-A488
Beschreibung:
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
VE:
1 * 100 µl
Artikel-Nr:
(1.08164.0001)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.08164.0001
Lokale Artikelnummer::
MERC1.08164.0001
Beschreibung:
Zur Kalibrierung von UV/VIS Spektralphotometern nach DAB und Ph. Eur.
VE:
1 * 3 Ampull
Artikel-Nr:
(BOSSBS-3766R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3766R
Lokale Artikelnummer::
BOSSBS-3766R
Beschreibung:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6634R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-CY5.5
Lokale Artikelnummer::
BOSSBS-6634R-CY5.5
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6634R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-A555
Lokale Artikelnummer::
BOSSBS-6634R-A555
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(5611-02)
Lieferant:
Avantor
Lokale Artikelnummer::
BAKR5611-02
Beschreibung:
Standardized at 25 °C against chemicals whose certification is traceable to NIST. Lot standardization value accurate to ±1 part per 1000, provided on label.
VE:
1 * 1 L
Artikel-Nr:
(ICNA195092.2)
Lieferant:
MP Biomedicals
Hersteller-Artikelnummer::
195092.2
Lokale Artikelnummer::
ICNA195092.2
Beschreibung:
Semi-synthetic antibiotic related to penicillin. It is a benzyl penicillin derivative with substitution of a-carboxyl group n the benzyl side chain. The product interferes with final cell wall synthesis of susceptible bacteria. It is completely ionized in the blood. Carbencillin disodium is about 50% reversibly protein bound in plasma and its tissue distribution is similar to other penicillins.
VE:
1 * 250 mg
Artikel-Nr:
(662-7373)
Lieferant:
WTW
Hersteller-Artikelnummer::
106661
Lokale Artikelnummer::
WTWA106661
Beschreibung:
Die bedienerfreundlichen, robusten, ionenselektiven Elektroden eignen sich ideal für den mobilen Einsatz.
VE:
1 * 1 ST
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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