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2\'-Amino-4\',5\'-dimethoxyacetophenon
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2\'-Amino-4\',5\'-dimethoxyacetophenon
Artikel-Nr:
(SIAL636320-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
636320-1G
Lokale Artikelnummer::
SIAL636320-1G
Beschreibung:
2-Amino-5-brompyrazin, Sigma-Aldrich®
VE:
1 * 1 g
Lieferant:
COMBI-BLOCKS
Beschreibung:
4-Amino-2-methylphenylboronsäurepinakolester
Lieferant:
Thermo Scientific
Beschreibung:
Methyl-2-amino-4-chlorbenzoat
Artikel-Nr:
(BOSSBS-13138R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13138R-CY3
Lokale Artikelnummer::
BOSSBS-13138R-CY3
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least eight complementation groups (A-G) have been identified and six FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF alpha signaling. Phosphorylation of FANC (Fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. FANCA, also known as FACA and FANCH, associates with the Brm-related gene 1 (BRG1) product, a subunit of the SWI/SNF complex which remodels chromatin structure through a DNA-dependent ATPase activity. FANCA is mainly expressed in lymphoid tissues, testis and ovary. The amino-terminal region of the FANCA protein is required for FANCG binding, FANCC binding, nuclear localization and functional activity of the complex. The human FANCA gene maps to chromosome 16q24.3 and encodes a 1,455 amino acid protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15486R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-HRP
Lokale Artikelnummer::
BOSSBS-15486R-HRP
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8341R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8341R-CY5.5
Lokale Artikelnummer::
BOSSBS-8341R-CY5.5
Beschreibung:
CPXM (carboxypeptidase X, member 1) belongs to the peptidase M14 family. However, no carboxypeptidase activity has yet been detected. It may be involved in cell-cell interactions.Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. Belonging to the N/E subfamily, CPXM (metallocarboxypeptidase CPX-1) is a 734 amino acid protein that contains a F5/8 type C domain and likely binds one zinc ion per subunit. Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide, and are thought to function mostly in protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway. CPXM is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily. Studies showing that CPXM expression is regulated during osteoclastogenesis suggest that CPXM may play a role in osteoclast differentiation. There are two isoforms of CPXM which are a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13647R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13647R-CY7
Lokale Artikelnummer::
BOSSBS-13647R-CY7
Beschreibung:
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family (1). JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, Ser-63 and Ser-73, resulting in transcriptional activation (2-5). Two additional JNK family members have been identified as JNK2 and JNK3 (3). JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding (6). Multiple splice variants if JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain (7).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15486R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-FITC
Lokale Artikelnummer::
BOSSBS-15486R-FITC
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8341R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8341R
Lokale Artikelnummer::
BOSSBS-8341R
Beschreibung:
CPXM (carboxypeptidase X, member 1) belongs to the peptidase M14 family. However, no carboxypeptidase activity has yet been detected. It may be involved in cell-cell interactions.Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. Belonging to the N/E subfamily, CPXM (metallocarboxypeptidase CPX-1) is a 734 amino acid protein that contains a F5/8 type C domain and likely binds one zinc ion per subunit. Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide, and are thought to function mostly in protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway. CPXM is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily. Studies showing that CPXM expression is regulated during osteoclastogenesis suggest that CPXM may play a role in osteoclast differentiation. There are two isoforms of CPXM which are a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(FLUO050234-5G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
050234-5G
Lokale Artikelnummer::
FLUO050234-5G
Beschreibung:
2-Amino-5-fluor-4-methylpyridin
VE:
1 * 5 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
Thermo Scientific
Beschreibung:
4-Amino-2,3,5,6-tetrachlorpyridin
Lieferant:
Sigma-Aldrich
Beschreibung:
2-Amino-6-brombenzothiazol, Sigma-Aldrich®
Lieferant:
COMBI-BLOCKS
Beschreibung:
2-Amino-5-chlor-4-methylpyridin
Lieferant:
FLUOROCHEM
Beschreibung:
4-Amino-8-(trifluormethyl)chinolin
Lieferant:
FLUOROCHEM
Beschreibung:
3-Amino-2,5-dichlorpyridin
Artikel-Nr:
(FLUO016128-1G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
016128-1G
Lokale Artikelnummer::
FLUO016128-1G
Beschreibung:
Ethyl-2-amino-4-oxazolcarboxylat
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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