Artikel-Nr:
(BOSSBS-11953R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11953R-A555
Lokale Artikelnummer::
BOSSBS-11953R-A555
Beschreibung:
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11953R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11953R-A488
Lokale Artikelnummer::
BOSSBS-11953R-A488
Beschreibung:
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11953R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11953R-A647
Lokale Artikelnummer::
BOSSBS-11953R-A647
Beschreibung:
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 15985-39-4
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 3687-18-1
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 1937-37-7
Artikel-Nr:
(BOSSBS-12574R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12574R-A555
Lokale Artikelnummer::
BOSSBS-12574R-A555
Beschreibung:
p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.
VE:
1 * 100 µl
Artikel-Nr:
(ACRO257721000)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
257721000
Lokale Artikelnummer::
ACRO257721000
Beschreibung:
CAS No.: 18695-01-7
VE:
1 * 100 mg
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 2528-00-9
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 1622-57-7
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 14782-58-2
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 614-39-1
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 10543-57-4
Artikel-Nr:
(ACRO257711000)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
257711000
Lokale Artikelnummer::
ACRO257711000
Beschreibung:
CAS-Nr.: 14206-58-7
VE:
1 * 100 mg
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 443-48-1
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 23359-08-2
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