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Strontiumperchlorat+Trihydrat
Artikel-Nr:
(BOSSBS-0573R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0573R-A750
Lokale Artikelnummer::
BOSSBS-0573R-A750
Beschreibung:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterised by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Transcript Variant: This variant contains a different 5' end region, which includes an upstream in-frame translation start codon, when compared to variant 2. The encoded protein has a 15 aa longer N-terminus, as compared to isoform 2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0802R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0802R-A750
Lokale Artikelnummer::
BOSSBS-0802R-A750
Beschreibung:
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1658R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1658R-CY5
Lokale Artikelnummer::
BOSSBS-1658R-CY5
Beschreibung:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1658R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1658R-FITC
Lokale Artikelnummer::
BOSSBS-1658R-FITC
Beschreibung:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(J62962.14)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
J62962.14
Lokale Artikelnummer::
ALFAJ62962.14
Beschreibung:
Trilaurin (Glycerintrilaurat)
VE:
1 * 25 g
Lieferant:
HICHROM GAS CHROMATOGRAPHY
Beschreibung:
Wirklich vielseitige polare Allzweck-Phase für eine Vielzahl von Anwendungen. Ideal für Bestätigungsanalysen. HI-17 MS ist eine kreuzgebundene Säule in MS-Qualität mit geringem Ausbluten, die eine lange Lebensdauer selbst bei hohen Temperaturgrenzen gewährleistet.
Artikel-Nr:
(BOSSBS-3196R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3196R-A488
Lokale Artikelnummer::
BOSSBS-3196R-A488
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2994R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2994R-A750
Lokale Artikelnummer::
BOSSBS-2994R-A750
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2994R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2994R-A680
Lokale Artikelnummer::
BOSSBS-2994R-A680
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Natriumorthovanadat 100 mM in wässriger Lösung
Lieferant:
Merck
Beschreibung:
Extrelut® NT ist ein speziell verarbeitetes, inertes, großporiges Kieselgur mit hohem Porenvolumen. Es wird wirksam eingesetzt in der klinischen Chemie und Toxikologie zur Probenvorbereitung von Urin, Blut, Plasma und sonstigen biologischen Matrizen. Weitere Anwendungen sind Umwelt- und Rückstandsanalysen, z. B. die Analyse von Industrie- und Haushaltsabwässern. Extrelut® NT ist fertig gepackt in Kartuschen oder als loses Sorbent erhältlich. Aufgrund seiner Oberflächeneigenschaften kann es als Basis für die Flüssig-Flüssig-Extraktion anstelle eines Scheidetrichters verwendet werden. Wenn eine wässrige Probe auf das Extrelut® NT Sorptionsmittel aufgetragen wird, verteilt es sich chemisch inerte Matrix und wirkt als stationäre Phase. Die Elution des zu untersuchenden Analyten erfolgt mit einem organischen Lösungsmittel, das nicht mit Wasser mischbar ist. Alle lipophilen Substanzen werden aus der wässrigen in die organische Phase extrahiert.
Lieferant:
Hichrom Limited
Beschreibung:
Diese LiChrospher®-Säulen bestehen aus Silica und sind sowohl mit endcapped als auch mit nicht endcapped C18-Phasen erhältlich. Diese Funktion verbessert die Selektivitätsoptionen für die Chromatographie.
Artikel-Nr:
(TCAT30213512)
Lieferant:
TECAN TRADING
Hersteller-Artikelnummer::
30213512
Lokale Artikelnummer::
TCAT30213512
Beschreibung:
Florisil is used for sample preparation (solid phase extraction) of e.g., organic tin compounds and aliphatic carboxylic acids. Florisil is a magnesium silicate.
VE:
1 * 50 ST
Lieferant:
NABERTHERM
Beschreibung:
Die hohe Beständigkeit der SiC-Stäbe beim periodischen Betrieb, kombiniert mit der hohen Aufheizgeschwindigkeit, macht diese Hochtemperaturöfen zu guten Allroundern im Laboreinsatz. Je nach Ofenmodell und Einsatzbedingungen können Aufheizzeiten von 40 Minuten auf 1400 °C erreicht werden.
Artikel-Nr:
(BOSSBS-0558R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0558R-A555
Lokale Artikelnummer::
BOSSBS-0558R-A555
Beschreibung:
Epithelial membrane protein-1 (EMP-1) is a four pass transmembrane protein consisting of 160 amino acids. It is a member of a small family of epithelial membrane proteins. EMP-1 is very similar in structure to its close relative, Peripheral Myelin Protein 22 (PMP22). It is most predominantly expressed in tissues of the gastrointestinal tract but has also been found to be a junctional protein in the liver expressed along the intercellular border. EMP-1 directly interacts with the C-terminus of the P2X7 receptor and may be involved in membrane blebbing. EMP-1 may also be an important regulator in cell communication, signaling, and adhesion. When EMP-1 is overexpressed, cell proliferation is inhibited, S phase is arrested and G1 phase is prolonged in esophogeal cancer cells. EMP-1 may play a role in tumorigenesis and has been identified as a biomarker for gefitinib treatment resistance for patients with lung cancer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0917R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0917R-FITC
Lokale Artikelnummer::
BOSSBS-0917R-FITC
Beschreibung:
Bromodeoxyuridine is a synthetic nucleoside that is an analogue of thymidine. BrdU is incorporated into DNA during S-phase of a cell cycle. It is commonly used in the detection of proliferating cells in living tissues
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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