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1,8-Dihydroxynaphthalin
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1,8-Dihydroxynaphthalin
Artikel-Nr:
(BOSSBS-5523R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5523R-FITC
Lokale Artikelnummer::
BOSSBS-5523R-FITC
Beschreibung:
Nudel is important for normal cortical development. It is invovled in microtubule organization, nuclear translocation, and neuronal positioning in concert with various other factors (including Lis1, Pafah1b1, Pahfah1b2, dynein, dynorphin A and cdk5). Western blot analysis of mouse tissues shows abundant expression of Nudel in brain and testis, and much lower expression in heart, liver, kidney, and skeletal muscle. In fractionated rat brain, Nudel and Lis1 are both found in fractions enriched for postsynaptic density proteins. Immunostaining of embryonic day 18 mouse brain sections revealed staining of migrating neurons and thalamocortical axons of the intermediate zone of the developing cerebral cortex, as well as several other developing brain regions. The deduced protein contains 345 amino acids and has a calculated molecular mass of 38.4 kDa. It has a coiled coil motif (residues 19 to 201), followed by several potential phosphorylation sites for casein kinase II, protein kinase C or CDK5. Nudel shares about 50% identity with mouse and human NUDE proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9380R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9380R-HRP
Lokale Artikelnummer::
BOSSBS-9380R-HRP
Beschreibung:
Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. OS-I mutations produce proteins with a decreased affinity for microtubules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11073R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11073R-A750
Lokale Artikelnummer::
BOSSBS-11073R-A750
Beschreibung:
The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding events that are critical to the maintenance of cell structure and morphogenesis. EY-cadherin, also known as CDH18 (cadherin 18), CDH14 (cadherin 14), CDH24 or CDH14L, is a 790 amino acid single-pass type I membrane protein that contains five cadherin domains. One of several members of the cadherin superfamily, EY-cadherin functions as a type II classical cadherin that is expressed specifically in the central nervous system (CNS), where it plays a role in cell-cell binding events. Specifically, EY-cadherin is thought to be involved in axon guidance and outgrowth, as well as synaptic adhesion within the CNS. EY-cadherin contains a highly conserved C-terminal domain characteristic of all cadherins, but lacks the HAV cell adhesion sequence that is specific to type I cadherins. The gene encoding EY-cadherin is located within a region on chromosome five that is commonly deleted in carcinomas, implicating EY-cadherin as a potential tumour suppressor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4141R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4141R-A680
Lokale Artikelnummer::
BOSSBS-4141R-A680
Beschreibung:
Nudel is important for normal cortical development. It is invovled in microtubule organisation, nuclear translocation, and neuronal positioning in concert with various other factors (including Lis1, Pafah1b1, Pahfah1b2, dynein, dynorphin A and cdk5). Western blot analysis of mouse tissues shows abundant expression of Nudel in brain and testis, and much lower expression in heart, liver, kidney, and skeletal muscle. In fractionated rat brain, Nudel and Lis1 are both found in fractions enriched for postsynaptic density proteins. Immunostaining of embryonic day 18 mouse brain sections revealed staining of migrating neurons and thalamocortical axons of the intermediate zone of the developing cerebral cortex, as well as several other developing brain regions. The deduced protein contains 345 amino acids and has a calculated molecular mass of 38.4 kDa. It has a coiled coil motif (residues 19 to 201), followed by several potential phosphorylation sites for casein kinase II, protein kinase C or CDK5. Nudel shares about 50% identity with mouse and human NUDE proteins.
VE:
1 * 100 µl
Lieferant:
DELTALAB
Beschreibung:
These screw caps are made of autoclavable PP.
Lieferant:
IMMUNOLOGIC
Beschreibung:
Cytokeratins 8 & 18 (CK 8 & 18) can be found in most simple epithelia, e.g. thyroid, breast, gastrointestinal tract, and respiratory tract. Adenocarcinomas and most non-keratinizing squamous carcinomas will stain with anti-CK 8 & 18, but keratinizing squamous carcinomas will not.<sup>1,2</sup> This antibody is used when attempting to demonstrate the presence of Paget cells; there is very little keratin 18 in the normal epidermis so this will only stain Paget cells.<sup>3</sup> The use of immunostaining facilitates interpretation and has been shown to be more sensitive than genetic analysis in colorectal carcinoma metastases.<sup>4</sup>
Artikel-Nr:
(217-9241)
Lieferant:
SEMADENI
Hersteller-Artikelnummer::
1515
Lokale Artikelnummer::
SEMA1515
Beschreibung:
Lamellar stoppers made from soft PE-LD.
VE:
1 * 100 ST
Artikel-Nr:
(SIAL274089-10G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
274089-10G
Lokale Artikelnummer::
SIAL274089-10G
Beschreibung:
2-Chlorbenzoxazol, Sigma-Aldrich®
VE:
1 * 10 g
Lieferant:
Merck
Beschreibung:
Porenvolumen: 2,9 ml/g.
Artikel-Nr:
(MART13-471-14)
Lieferant:
KLS Martin Group
Hersteller-Artikelnummer::
13-471-14
Lokale Artikelnummer::
MART13-471-14
Beschreibung:
Stainless steel.
VE:
1 * 1 ST
Artikel-Nr:
(CHMPML00094.250)
Lieferant:
CHEMPUR
Hersteller-Artikelnummer::
ML00094.250
Lokale Artikelnummer::
CHMPML00094.250
Beschreibung:
Carbohydrazid
VE:
1 * 250 mg
Artikel-Nr:
(BOCH5306)
Lieferant:
BOCHEM
Hersteller-Artikelnummer::
5306
Lokale Artikelnummer::
BOCH5306
Beschreibung:
Cross type double bossheads, either made of stainless steel or malleable cast iron, chromium plated.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-5973R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5973R-FITC
Lokale Artikelnummer::
BOSSBS-5973R-FITC
Beschreibung:
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
VE:
1 * 100 µl
Lieferant:
Sampling Systems
Beschreibung:
These scoops made from 304 stainless steel are ideal for general industrial use.
Artikel-Nr:
(PRSI33-433)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-433
Lokale Artikelnummer::
PRSI33-433
Beschreibung:
This mAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI33-430)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-430
Lokale Artikelnummer::
PRSI33-430
Beschreibung:
This mAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
VE:
1 * 100 µG
New Product
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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